| Alterations of myoepithelial cells in the rat mammary gland during pregnancy, lactation and involution, and after estradiol treatment. | |
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MedLine Citation:
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PMID: 10849327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hormone-induced alterations of myoepithelial cells in the mammary gland have not been fully investigated. The aim of the present study was to examine whether myoepithelial cells are altered in response to hormonal conditions. The immunohistochemical findings of smooth muscle actin for myoepithelial cells were studied during pregnancy, lactation and involution, and after estradiol dipropionate (ED) treatment (50, 500, 1000 microg/kg per week for 1-4 weeks) using a total of 71 Wistar female rats. Myoepithelial cells showed a stratified appearance around ducts during pregnancy, extended cytoplasmic processes with wider distance during lactation, and vacuolated cytoplasm after weaning. ED treatment (50-1000 microg/kg per week) for 1 week increased myoepithelial cells to a variable degree, achieving a level similar to that in pregnancy, but ED treatment for 4 weeks reduced them as the dose elevated. The present study showed that the myoepithelial cells became hyperplastic or hypertrophic by low-dose ED treatment within the physiological range, while weaning pups, and excess high-dose ED treatment beyond the physiological range or prolonged ED treatment induced reduction of the myoepithelial cells. Results indicate that myoepithelial cells themselves are also altered by hormonal conditions coordinating the mammary gland development. |
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Authors:
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H S Jin; S Umemura; T Iwasaka; R Y Osamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pathology international Volume: 50 ISSN: 1320-5463 ISO Abbreviation: Pathol. Int. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-08-10 Completed Date: 2000-08-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 384-91 Citation Subset: IM |
Affiliation:
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Department of Pathology, Tokai University School of Medicine, Isehara, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Animals Cell Count Cell Size Dose-Response Relationship, Drug Epithelial Cells / drug effects*, metabolism, pathology Estradiol / analogs & derivatives*, pharmacology Female Fluorescent Antibody Technique, Indirect Hyperplasia Lactation* Mammary Glands, Animal / drug effects*, metabolism, pathology Pregnancy Pregnancy, Animal* Rats Rats, Wistar Weaning |
| Chemical | |
Reg. No./Substance:
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0/Actins; 113-38-2/estradiol dipropionate; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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