Document Detail

Alterations of myoepithelial cells in the rat mammary gland during pregnancy, lactation and involution, and after estradiol treatment.
MedLine Citation:
PMID:  10849327     Owner:  NLM     Status:  MEDLINE    
Hormone-induced alterations of myoepithelial cells in the mammary gland have not been fully investigated. The aim of the present study was to examine whether myoepithelial cells are altered in response to hormonal conditions. The immunohistochemical findings of smooth muscle actin for myoepithelial cells were studied during pregnancy, lactation and involution, and after estradiol dipropionate (ED) treatment (50, 500, 1000 microg/kg per week for 1-4 weeks) using a total of 71 Wistar female rats. Myoepithelial cells showed a stratified appearance around ducts during pregnancy, extended cytoplasmic processes with wider distance during lactation, and vacuolated cytoplasm after weaning. ED treatment (50-1000 microg/kg per week) for 1 week increased myoepithelial cells to a variable degree, achieving a level similar to that in pregnancy, but ED treatment for 4 weeks reduced them as the dose elevated. The present study showed that the myoepithelial cells became hyperplastic or hypertrophic by low-dose ED treatment within the physiological range, while weaning pups, and excess high-dose ED treatment beyond the physiological range or prolonged ED treatment induced reduction of the myoepithelial cells. Results indicate that myoepithelial cells themselves are also altered by hormonal conditions coordinating the mammary gland development.
H S Jin; S Umemura; T Iwasaka; R Y Osamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  50     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-10     Completed Date:  2000-08-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  384-91     Citation Subset:  IM    
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
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MeSH Terms
Actins / metabolism
Cell Count
Cell Size
Dose-Response Relationship, Drug
Epithelial Cells / drug effects*,  metabolism,  pathology
Estradiol / analogs & derivatives*,  pharmacology
Fluorescent Antibody Technique, Indirect
Mammary Glands, Animal / drug effects*,  metabolism,  pathology
Pregnancy, Animal*
Rats, Wistar
Reg. No./Substance:
0/Actins; 113-38-2/estradiol dipropionate; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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