Document Detail


Alterations of motor nerve functions in animals exposed to motorcycle exhaust.
MedLine Citation:
PMID:  12079615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of motorcycle exhaust (ME) on the motor nerve was studied using animals exposed to the exhaust by inhalation, intratracheal, or intraperitoneal administration of ME particulate (MEP). A 4-wk ME inhalation and intratracheal instillation of MEP for 1 d in rats or intraperitoneal administration of MEP (0.5 g/kg/d for 1 d and 0.1 g/kg/d for 2 d) in mice significantly decreased both rota-rod performance and motor nerve conduction velocity. The effect of some polycyclic aromatic hydrocarbons on the motor nerve was also investigated. Treatment with benzo[a]pyrene (0.05 and 0.1 g/kg/d for 3 d), but not pyrene (0.1 g/kg/d for 3 d), resulted in significant decrease of motor nerve conduction velocity in mice. Moreover, the Na(+),K(+)-ATPase activities of sciatic nerves isolated from ME-, MEP-, or benzo[a]pyrene-exposed animals were decreased. Treatment with pyrene did not markedly affect the Na(+),K(+)-ATPase activity of sciatic nerve. The rats exposed to ME for 4 wk showed increases in blood and sciatic nerve manganese levels. Results indicate that motorcycle exhaust produces adverse effects on the motor nerve, which is associated with a fall in nerve Na(+),K(+)-ATPase activity.
Authors:
Shing-Hwa Liu; Jei-Hui Wang; Jiunn-Jye Chuu; Shoei-Yn Lin-Shiau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  65     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-24     Completed Date:  2002-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  803-12     Citation Subset:  IM    
Affiliation:
Institute of Toxicology, Medical College, National Taiwan University, Taipei, Taiwan. shliu@ha.mc.ntu.edu.tw
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Benzo(a)pyrene / administration & dosage,  adverse effects
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Intubation, Intratracheal
Male
Manganese / blood,  metabolism
Mice
Mice, Inbred ICR
Motor Skills / drug effects
Motorcycles
Neural Conduction / drug effects*
Polycyclic Hydrocarbons, Aromatic / administration & dosage,  adverse effects*
Pyrenes / administration & dosage,  adverse effects
Rats
Rats, Wistar
Sciatic Nerve / drug effects*,  enzymology
Sodium-Potassium-Exchanging ATPase / metabolism*
Vehicle Emissions / adverse effects*
Chemical
Reg. No./Substance:
0/Polycyclic Hydrocarbons, Aromatic; 0/Pyrenes; 0/Vehicle Emissions; 129-00-0/pyrene; 50-32-8/Benzo(a)pyrene; 7439-96-5/Manganese; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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