Document Detail

Alterations of membrane glycoproteins in malignant cells.
MedLine Citation:
PMID:  223919     Owner:  NLM     Status:  MEDLINE    
Comparisons have been made of the carbohydrates bound to membrane proteins of control and malignant cells in culture. It has been found that most individual glycoproteins of control and malignant cells differ in their carbohydrate components. Differences between control and malignant cells have been foundin the glycoproteins of the various membrane systems (surface, nucleus, mitochondria, endoplasmic reticulum). It is suggested that the extensive changes in bound carbohydrates of the malignant cell permit the cell to live and divide but isolate the cell functionally. The extensive structural changes may also be responsible for the cascading of involvement of various processes within the malignant cell.
L Warren; C A Buck; G P Tuszynski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Developments in biological standardization     Volume:  42     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1979  
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
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MeSH Terms
Avian Sarcoma Viruses
Carbohydrates / analysis
Cell Line
Cell Transformation, Neoplastic
Cell Transformation, Viral
Glycopeptides / analysis
Glycoproteins / analysis*
Membrane Proteins / analysis*
Neoplasm Proteins / analysis*
Reg. No./Substance:
0/Carbohydrates; 0/Glycopeptides; 0/Glycoproteins; 0/Membrane Proteins; 0/Neoplasm Proteins

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