| Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension. | |
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MedLine Citation:
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PMID: 6097234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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104 spontaneously hypertensive rats (SHR) and 107 normotensive control rats (WR) fed a commercial diet were sacrificed at 4, 8, 26 and 52 weeks of age. The kidneys were immediately removed and carefully separated into cortex and medulla. In general, the triglyceride levels in renal medulla appeared higher when compared with the cortex. On the other hand, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were usually higher in the cortex and increased with age. In the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension, the percentage of linoleic acid (LA) in triglycerides and of arachidonic acid (AA) in PC was decreased. This was associated with an increase of AA in free fatty acids (FFA), indicating an enhanced activity of phospholipase A2. Furthermore, a fall of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE of kidneys in SHR at 8 weeks of age could be found. The data suggest that systematic alterations in the availability of individual polyunsaturated fatty acids in various renal lipids might be related to the onset of hypertension in SHR. Age-dependent changes in enzymes involved in prostaglandin formation should be considered as an adaptive mechanism which is insufficient to reduce or abolish genetically determined hypertension in SHR. |
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Authors:
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P Singer; M Wirth; U Gerike; W Gödicke; V Moritz |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 43 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1984 |
Date Detail:
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Created Date: 1985-02-05 Completed Date: 1985-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: S247-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Arachidonic Acid Arachidonic Acids / metabolism* Eicosapentaenoic Acid Fatty Acids, Unsaturated / metabolism* Hypertension / metabolism* Kidney / metabolism Kidney Cortex / growth & development* Kidney Medulla / growth & development* Linoleic Acid Linoleic Acids / metabolism* Rats Rats, Inbred SHR Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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