Document Detail

Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension.
MedLine Citation:
PMID:  6097234     Owner:  NLM     Status:  MEDLINE    
104 spontaneously hypertensive rats (SHR) and 107 normotensive control rats (WR) fed a commercial diet were sacrificed at 4, 8, 26 and 52 weeks of age. The kidneys were immediately removed and carefully separated into cortex and medulla. In general, the triglyceride levels in renal medulla appeared higher when compared with the cortex. On the other hand, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were usually higher in the cortex and increased with age. In the kidneys of SHR at 8 weeks of age, i.e. during the development of hypertension, the percentage of linoleic acid (LA) in triglycerides and of arachidonic acid (AA) in PC was decreased. This was associated with an increase of AA in free fatty acids (FFA), indicating an enhanced activity of phospholipase A2. Furthermore, a fall of eicosapentaenoic acid (EPA) in triglycerides, FFA, PC and PE of kidneys in SHR at 8 weeks of age could be found. The data suggest that systematic alterations in the availability of individual polyunsaturated fatty acids in various renal lipids might be related to the onset of hypertension in SHR. Age-dependent changes in enzymes involved in prostaglandin formation should be considered as an adaptive mechanism which is insufficient to reduce or abolish genetically determined hypertension in SHR.
P Singer; M Wirth; U Gerike; W Gödicke; V Moritz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  43     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-05     Completed Date:  1985-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  S247-50     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism*
Eicosapentaenoic Acid
Fatty Acids, Unsaturated / metabolism*
Hypertension / metabolism*
Kidney / metabolism
Kidney Cortex / growth & development*
Kidney Medulla / growth & development*
Linoleic Acid
Linoleic Acids / metabolism*
Rats, Inbred SHR
Rats, Inbred Strains
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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