| Alterations in ventilatory pattern and ratio of dead-space to tidal volume. | |
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MedLine Citation:
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PMID: 3119296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of alterations in ventilatory pattern on the simultaneously measured physiologic and anatomic dead-spaces (VDphys and VDan, respectively) and the dead-space to tidal volume ratio (VD-VT) were studied in 17 healthy normal subjects (13 men, four women, ages 21 to 36 years). There were no significant changes in VDan with increases in respiratory frequency (f) or tidal volume (VT). The VDphys increased (mean change +0.153 L, p less than 0.05) with increase in VT (mean increase +0.84 L, p less than 0.01), but did not alter significantly with a twofold increase in f, at control VT. Increase in VT significantly reduced VD/VT (mean change -10.4 percent, p less than 0.05), but increase in f, at control VT, did not significantly alter VD/VT. These results indicate that in normal subjects, increase in VT alters ventilation/perfusion matching in the lungs, whereas an increase in f, at constant VT, has no effect on ventilation/perfusion matching. Increases in VD/VT cannot, therefore, be ascribed to alterations in ventilatory pattern where either VT, or f, or both are increased. |
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Authors:
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R W Baker; N K Burki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 92 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-01-13 Completed Date: 1988-01-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1013-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Kentucky Medical Center, Lexington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / analysis Female Humans Lung / physiology Lung Volume Measurements* Male Respiration Respiratory Dead Space* Tidal Volume* Vital Capacity |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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