Document Detail

Alterations in trace elements and oxidative stress in uremic patients with dementia.
MedLine Citation:
PMID:  19242659     Owner:  NLM     Status:  MEDLINE    
The present study was conducted to compare the trace elements and oxidative status between uremic patients with and without dementia. Chronic hemodialysis patients with dementia (n = 20) and without dementia (n = 25), and age-matched healthy volunteers (n = 20) were enrolled. The nutritional status, blood levels of trace elements aluminum (Al), zinc (Zn), copper (Cu), magnesium (Mg) and iron (Fe), malondialdehyde (MDA), and protein carbonyl production, antioxidant enzymes glutathione peroxidase (GPx), and glutathione reductase (GR) activities were measured. No significant difference in nutritional status or clinical characteristics was observed between nondementia and dementia patients. However, uremic patients with dementia have significantly higher Al, Cu, and Mg and lower Zn concentrations, as well as increased Cu/Zn ratio in comparison to nondementia patients. There were statistically significant increased MDA and carbonyl production and decreased GPx and GR activities in dementia patients. Furthermore, the significant associations of Al, Mg, and Cu/Zn ratio with oxidative status in patients with dementia were noted. The dementia may initially worsen with abnormal metabolism of trace elements and oxidative stress occurrence. Our results suggest that abnormalities in trace element levels are associated with oxidative stress and may be a major risk factor in the dementia development of uremic patients.
Chih-Hung Guo; Wang-Sheng Ko; Pei-Chung Chen; Guoo-Shyng W Hsu; Chia-Yeh Lin; Chia-Liang Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-26
Journal Detail:
Title:  Biological trace element research     Volume:  131     ISSN:  1559-0720     ISO Abbreviation:  -     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-24     Citation Subset:  IM    
Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan, Republic of China.
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MeSH Terms
Aged, 80 and over
Copper / blood
Dementia / blood,  complications*,  metabolism*
Iron / blood
Magnesium / blood
Middle Aged
Oxidative Stress / physiology*
Trace Elements / metabolism*
Uremia / complications*,  physiopathology*
Zinc / blood
Reg. No./Substance:
0/Trace Elements; 7439-89-6/Iron; 7439-95-4/Magnesium; 7440-50-8/Copper; 7440-66-6/Zinc

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