Document Detail

Alterations in tight junction molecules of uterine epithelial cells during early pregnancy in the rat.
MedLine Citation:
PMID:  12086335     Owner:  NLM     Status:  MEDLINE    
Distribution patterns of the tight junction associated proteins ZO-1, claudin-1 and occludin were investigated in rat uterine epithelial cells during early pregnancy. Light microscopy and immunohistochemical labelling were used to detect these proteins on days 1, 3, 6 and 7 of pregnancy. Intense staining of claudin-1 at the apical region of the lateral plasma membrane accompanied diffuse staining throughout the cytoplasm. ZO-1 was also localised in the apical region, but ZO-1 was not present in the lower two thirds of the lateral plasma membrane or in the cytoplasm. Occludin was present only on days 6 and 7 of pregnancy. Labelling was also localised in the apical region of the lateral plasma membrane where tight junctions are known to be present. Our results show that ZO-1, claudin-1 and occludin are present in the apical region of uterine epithelial cells, and appear to play a role in the very dynamic tight-junctional network of uterine epithelial cells during early pregnancy. In particular, occludin appears only during uterine receptivity for implantation.
Megan D Orchard; Christopher R Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  104     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-12-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Department of Anatomy and Histology, The University of Sydney, NSW, Australia.
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MeSH Terms
Cell Membrane / metabolism,  ultrastructure
Coloring Agents
Endometrium / metabolism,  physiology,  ultrastructure
Epithelial Cells / physiology*,  ultrastructure
Fluorescent Antibody Technique
Immunoenzyme Techniques
Membrane Proteins / metabolism,  physiology
Microscopy, Fluorescence
Phosphoproteins / metabolism,  physiology
Pregnancy, Animal / physiology*
Rats, Wistar
Tight Junctions / physiology*,  ultrastructure
Uterus / cytology,  physiology*,  ultrastructure
Reg. No./Substance:
0/Coloring Agents; 0/Membrane Proteins; 0/Phosphoproteins; 0/claudin 1; 0/occludin; 0/zonula occludens-1 protein

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