| Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl) phthalate or with hypolipidaemic agents. | |
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MedLine Citation:
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PMID: 3341048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of rats for periods of 3 months or longer with the hypolipidaemic drugs clofibrate and fenofibrate or with the plasticiser di-(2-ethylhexyl) phthalate causes alterations in the thyroid. The colloid is shrunken and contains calcium-rich inclusions. Electron microscopy shows increases in the number and size of lysosomes, hypertrophy of the Golgi apparatus and dilation of the rough endoplasmic reticulum. These changes are consistent with persistent hyperactivity in the gland. |
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Authors:
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S C Price; D Chescoe; P Grasso; M Wright; R H Hinton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 40 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-03-03 Completed Date: 1988-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 37-46 Citation Subset: IM |
Affiliation:
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Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clofibrate / toxicity* Diethylhexyl Phthalate / toxicity* Electron Probe Microanalysis Iodine / metabolism Lysosomes / metabolism Microscopy, Electron Phthalic Acids / toxicity* Plasticizers / toxicity* Procetofen / toxicity* Propionates / toxicity* Rats Thyroid Gland / drug effects*, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Phthalic Acids; 0/Plasticizers; 0/Propionates; 117-81-7/Diethylhexyl Phthalate; 49562-28-9/Procetofen; 637-07-0/Clofibrate; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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