Document Detail

Alterations in sodium metabolism as an etiological model for hypertension.
MedLine Citation:
PMID:  8527348     Owner:  NLM     Status:  MEDLINE    
An adequate matching for race, sex, stage of the menstrual cycle, family history of hypertension, and the amount of sodium and other electrolytes in the diet should be a prerequisite for valid conclusions when interpreting the erythrocyte concentration and fluxes of sodium in essential hypertensive patients in comparison with normal subjects. Alterations in intracellular sodium concentration and transmembrane sodium transport systems as causes of essential hypertension are postulated. This review article describes how this abnormal sodium and calcium metabolism translates into increased systemic vascular resistance through altered vasoactive responses and/or vasculature structural changes.
P Lijnen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  9     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-02-01     Completed Date:  1996-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-99     Citation Subset:  IM    
Department of Molecular and Cardiovascular Research, University of Leuven, Belgium.
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MeSH Terms
Antiporters / metabolism*,  physiology
Bicarbonates / metabolism
Blood Pressure / physiology
Calcium / metabolism
Chlorides / metabolism
Erythrocytes / cytology,  metabolism
Hypertension / etiology*,  metabolism
Ion Transport
Lithium / metabolism*
Sodium / metabolism*
Sodium-Hydrogen Antiporter / metabolism*,  physiology
Sodium-Potassium-Exchanging ATPase / metabolism
Vascular Resistance / physiology
Reg. No./Substance:
0/Antiporters; 0/Bicarbonates; 0/Chlorides; 0/Sodium-Hydrogen Antiporter; 0/sodium-lithium countertransporter; 7439-93-2/Lithium; 7440-23-5/Sodium; 7440-70-2/Calcium; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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