Document Detail

Alterations in skeletal muscle morphology in glucose-tolerant elderly hypertensive men: relationship to development of hypertension and heart rate.
MedLine Citation:
PMID:  10826558     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the muscle morphology in hypertensive subjects with that in controls and to test the hypothesis of a relation between heart rate, development of hypertension and muscle morphology that is independent of glucose intolerance. PATIENTS AND METHODS: We studied 43 glucose-tolerant, untreated hypertensive subjects and 113 healthy controls in a longitudinal cohort of 70-year-old men. Metabolic status (oral glucose tolerance test and euglycemic, hyperinsulinaemic clamp test), muscle fibre distribution (myosin ATPase staining) and capillary supply (amylase-PAS method) were evaluated. Blood pressure and heart rate data were available from both ages 50 and 70 years. RESULTS: Hypertensive subjects had a significantly smaller mean number of capillaries per fibre than controls (1.53 versus 1.64; P = 0.04). In hypertensive subjects, the proportions of type I and type II fibres were correlated to mean arterial pressure (r = -0.56 and r= 0.52, respectively, P < 0.05 for both). The increase in mean arterial pressure over 20 years was closely correlated to capillary density in mm2 (r= -0.62; P< 0.0001). Capillary supply was inversely related to resting heart rate both at ages 50 and 70 years. CONCLUSIONS: Skeletal muscle of glucose tolerant hypertensive subjects showed a lower capillary supply than that of controls. This capillary rarefaction was correlated to increase in mean arterial pressure over two decades and to supine heart rate. This is compatible with the suggestion that higher sympathetic drive might generate structural alterations in muscle capillarization.
A Hedman; R Reneland; H O Lithell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  18     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-18     Completed Date:  2000-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  559-65     Citation Subset:  IM; S    
Department of Public Health and Caring Sciences/Section of Geriatrics, Uppsala University, Sweden.
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MeSH Terms
Blood Pressure / physiology
Body Mass Index
Capillaries / pathology
Case-Control Studies
Cohort Studies
Glucose Tolerance Test
Heart Rate / physiology*
Hypertension / etiology,  pathology*,  physiopathology*
Longitudinal Studies
Middle Aged
Muscle Fibers, Fast-Twitch / pathology
Muscle Fibers, Slow-Twitch / pathology
Muscle, Skeletal / blood supply*,  pathology*

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