| Alterations in serum lipid profile patterns in oral squamous cell carcinoma patients. | |
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MedLine Citation:
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PMID: 22269236 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: Altered lipid profile patterns have been associated with malignancies because lipids play a pivotal role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in oral squamous cell carcinoma patients as well as its association with the habit of tobacco consumption. Materials and methods: The study included 30 oral squamous cell carcinoma patients, 20 patients with the habit of tobacco consumption and 20 controls. Serum lipids, including (i) total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC), (iv) VLDL cholesterol (VLDLC) and (v) triglycerides, were analyzed by spectrophotometric kits. Results: A significant decrease in serum total cholesterol (TC) levels, triglyceride levels (p = 0.007, p = 0.029 respectively) were observed in oral squamous cell carcinoma patients as compared to the healthy control group. The mean serum HDLC levels (p = 0.003) were significantly lowered in the tobacco habituates when compared to the healthy controls. The mean serum total cholesterol levels were significantly lower in subjects with oral squamous cell carcinoma (p = 0.000) as compared to the tobacco habituates. Likewise, LDLC levels and TC:HDLC ratios (p = 0.000 and p = 0.000 respectively) were significantly decreased in oral squamous cell carcinoma patients as compared to the tobacco habituates. Our data strengthens the evidence of an inverse relationship between serum lipid levels and oral squamous cell carcinoma. Conclusion: The lower level of serum cholesterol and other lipid constituents in the patients is thought to be due to their increased usage by tumor cells for new membrane biogenesis. Clinical significance: The lower serum lipid profile status serves as a useful indicator for gauging initial changes occurring in tumor cells. A detailed study of the cholesterol carrying lipoprotein transport mechanisms helps in better understanding of the underlying mechanisms of the regulation of serum cholesterol concentrations in cancer. Keywords: High-density lipids, Low-density lipids, Very lowdensity lipids, Cholesterol, Triglycerides, Oral squamous cell carcinoma, Case control study. How to cite this article: Ghosh G, Jayaram KM, Patil RV, Malik S. Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients. J Contemp Dent Pract 2011;12(6): 451-456. Source of support: Nil Conflict of interest: None declared. |
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Authors:
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Gaurav Ghosh; Krithika M Jayaram; Rekha V Patil; Sangeeta Malik |
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Publication Detail:
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Type: Journal Article Date: 2011-11-01 |
Journal Detail:
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Title: The journal of contemporary dental practice Volume: 12 ISSN: 1526-3711 ISO Abbreviation: J Contemp Dent Pract Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101090552 Medline TA: J Contemp Dent Pract Country: United States |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: D; IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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