Document Detail


Alterations in serum creatine kinase and lactate dehydrogenase. Association with abdominal aortic surgery, myocardial infarction and bowel necrosis.
MedLine Citation:
PMID:  2306954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental studies have shown that peripheral serum creatine kinase and lactate dehydrogenase change with bowel infarction. Some clinical reports have suggested that similar changes occur in patients. This prospective study documents the changes in these enzymes associated with acute myocardial infarction, acute bowel necrosis (MES INF), and uncomplicated abdominal aortic reconstruction. Analysis of 15 patients with AMI, 13 patients undergoing major AAS, and eight patients with MES INF has shown that these conditions may be differentiated by analysis of serum CK and LD isoenzymes. The study suggests that in the absence of electrocardiographic changes, a patient with epigastric distress with elevated levels of serum CK and either CK-MB or CK-BB bands present may well have a mesenteric rather than a myocardial infarction. Acute myocardial infarction can be ruled out further through analysis of serum LD1/LD2 ratios.
Authors:
G M Graeber; G P Clagett; R E Wolf; P J Cafferty; J W Harmon; N M Rich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  97     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-02     Completed Date:  1990-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-7     Citation Subset:  AIM; IM    
Affiliation:
Division of Surgery, Walter Reed Army Institute of Research, Washington, DC.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aorta, Abdominal / surgery
Aortic Diseases / enzymology*,  surgery
Creatine Kinase / blood*
Electrocardiography
Electrophoresis, Agar Gel
Female
Humans
Infarction / enzymology*
Intestines / blood supply*
Isoenzymes
L-Lactate Dehydrogenase / blood*
Male
Middle Aged
Myocardial Infarction / enzymology*
Necrosis
Prospective Studies
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase
Comments/Corrections
Comment In:
Chest. 1990 Mar;97(3):519-20   [PMID:  2407449 ]

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