Document Detail

Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia.
MedLine Citation:
PMID:  19573524     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Preeclampsia, a pregnancy-specific complication occurring in the second half of human pregnancy and one of the leading causes for perinatal mortality and morbidity, is characterized by the onset of hypertension and proteinuria. We measured circulating adipocyte fatty acid binding protein (AFABP) and retinol binding protein-4 (RBP-4) in patients with preeclampsia. METHODS: Twenty-seven healthy non-pregnant women, 27 healthy pregnant women at third trimester and 26 women with preeclampsia were recruited and blood samples were taken. Concentrations of serum AFABP and RBP-4 were measured with ELISA. RESULTS: There were significant differences in serum AFABP (median: 0.99, 0.93 and 1.81ng/ml, respectively, P<0.001) and RBP-4 (mean: 3.16, 2.65 and 4.27ng/ml, respectively, P=0.022) among non-pregnancy, normal pregnancy and preeclampsia. Serum AFABP was significantly higher in preeclampsia than non-pregnancy (P<0.001) and normal pregnancy (P=0.001). Serum RBP-4 was significantly higher in preeclampsia than normal pregnancy (P=0.007) but not non-pregnancy (P=0.061). There were no significant differences in serum RBP-4 and AFABP between non-pregnancy and normal pregnancy. Serum RBP-4 was significantly higher in severe than mild preeclampsia (mean: 5.15 vs 2.84ng/ml, P=0.046). There was no significant difference in serum AFABP between mild and severe preeclampsia. CONCLUSION: Increased circulating AFABP and RBP-4 concentrations were demonstrated, suggesting it be an important pathophysiology of preeclampsia.
Xuejun Shangguan; Fengjuan Liu; Hanzhi Wang; Jing He; Minyue Dong
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Publication Detail:
Type:  Journal Article     Date:  2009-06-29
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  407     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  58-61     Citation Subset:  IM    
Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Women's Reproductive Health of Zhejiang Province, China.
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MeSH Terms
Case-Control Studies
Fatty Acid-Binding Proteins / blood*
Pre-Eclampsia / blood*,  pathology
Pregnancy / blood*
Retinol-Binding Proteins, Plasma / metabolism*
Young Adult
Reg. No./Substance:
0/FABP4 protein, human; 0/Fatty Acid-Binding Proteins; 0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma

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