| Alterations in respiratory mechanics in mechanically ventilated patients following bronchoalveolar lavage. | |
| | |
MedLine Citation:
|
PMID: 19773208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/PURPOSE: Bronchoalveolar lavage (BAL) can be used for a variety of diagnostic purposes in mechanically ventilated patients. BAL can cause changes in respiratory mechanics. However, the risk factors associated with these changes remain unknown. The current study tried to identify the risk factors that contribute to changes in respiratory mechanics following BAL. METHODS: Changes in respiratory mechanics were assessed in 56 mechanically ventilated patients who received BAL using an interrupter method under constant flow. RESULTS: Intrinsic positive end-expiratory pressure (PEEPi) was correlated significantly with changes in respiratory system resistance and compliance following BAL in mechanically ventilated patients (p = 0.003). In 14 patients with PEEPi > 1 cmH2O, maximal resistance (Rmax) before BAL was 22.5 +/- 5.9 cmH2O/L/S, increasing to 31.6 +/- 8.5 cmH2O/L/S immediately after BAL, and remaining high (28.4 +/- 7.5 cmH2O/L/S) 30 minutes later (p < 0.001). Increase in minimal resistance (Rmin), delta resistance (DeltaR), and decrease in compliance followed the same time trend. In 42 patients with PEEPi < or = 1 cmH2O, Rmax before BAL was 15.5 +/- 3.5 cmH2O/L/S, increasing to 17.6 +/- 4.6 cmH2O/L/S immediately after BAL, and decreasing to 16.6 +/- 4.3 cmH2O/L/S (p < 0.001) 30 minutes later. Increase in Rmin, DeltaR and decrease in compliance were similar to those seen with Rmax. Increases in Rmax, Rmin and DeltaR, and decrease in compliance following BAL were significantly higher in patients with significant PEEPi than in those without throughout the recording period (p < 0.001). CONCLUSION: Patients with significant PEEPi experienced greater changes in respiratory mechanics than those without. Physicians should be cautious when performing BAL in such patients. |
| | |
Authors:
|
Meng-Yi Chou; Chih-Ying Ou; Chang-Wen Chen |
Related Documents
:
|
18804848 - The impact of the pai-1 4g/5g polymorphism on the outcome of patients with ali/ards. 18284668 - Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patie... 6728668 - Pyometra in the dog--a pathophysiological investigation. vi: acid-base status and serum... 21028 - Effect of metabolic alkalosis on respiratory function in patients with chronic obstruct... 19432688 - Treatment of severe metastatic calcification in hemodialysis patients. 15810948 - Severe gastritis in the peruvian andes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 108 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-23 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 704-12 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Chia-Li Hospital, Tainan, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Bronchoalveolar Lavage* Female Humans Male Middle Aged Positive-Pressure Respiration Respiration, Artificial* Respiratory Mechanics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Timing of Acute Respiratory Distress Syndrome Onset is Related to Patient Outcome.
Next Document: Diagnostic Value of Finger-guided Prostate Nodule Biopsy Combined With Systemic Random Biopsy.