Document Detail

Alterations in respiratory mechanics in mechanically ventilated patients following bronchoalveolar lavage.
MedLine Citation:
PMID:  19773208     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Bronchoalveolar lavage (BAL) can be used for a variety of diagnostic purposes in mechanically ventilated patients. BAL can cause changes in respiratory mechanics. However, the risk factors associated with these changes remain unknown. The current study tried to identify the risk factors that contribute to changes in respiratory mechanics following BAL. METHODS: Changes in respiratory mechanics were assessed in 56 mechanically ventilated patients who received BAL using an interrupter method under constant flow. RESULTS: Intrinsic positive end-expiratory pressure (PEEPi) was correlated significantly with changes in respiratory system resistance and compliance following BAL in mechanically ventilated patients (p = 0.003). In 14 patients with PEEPi > 1 cmH2O, maximal resistance (Rmax) before BAL was 22.5 +/- 5.9 cmH2O/L/S, increasing to 31.6 +/- 8.5 cmH2O/L/S immediately after BAL, and remaining high (28.4 +/- 7.5 cmH2O/L/S) 30 minutes later (p < 0.001). Increase in minimal resistance (Rmin), delta resistance (DeltaR), and decrease in compliance followed the same time trend. In 42 patients with PEEPi < or = 1 cmH2O, Rmax before BAL was 15.5 +/- 3.5 cmH2O/L/S, increasing to 17.6 +/- 4.6 cmH2O/L/S immediately after BAL, and decreasing to 16.6 +/- 4.3 cmH2O/L/S (p < 0.001) 30 minutes later. Increase in Rmin, DeltaR and decrease in compliance were similar to those seen with Rmax. Increases in Rmax, Rmin and DeltaR, and decrease in compliance following BAL were significantly higher in patients with significant PEEPi than in those without throughout the recording period (p < 0.001). CONCLUSION: Patients with significant PEEPi experienced greater changes in respiratory mechanics than those without. Physicians should be cautious when performing BAL in such patients.
Meng-Yi Chou; Chih-Ying Ou; Chang-Wen Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  108     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-23     Completed Date:  2010-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  704-12     Citation Subset:  IM    
Department of Internal Medicine, Chia-Li Hospital, Tainan, Taiwan.
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MeSH Terms
Bronchoalveolar Lavage*
Middle Aged
Positive-Pressure Respiration
Respiration, Artificial*
Respiratory Mechanics*

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