| Alterations in rat alveolar surfactant system induced by treatment with carbicron (O-[(2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate). | |
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MedLine Citation:
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PMID: 1363304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Intoxication of rats with carbicron (O-([2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate) induced a reduction of the total phospholipids and phosphatidylcholine in lung alveolar surfactant. 2. The lipid transfer protein activity was inhibited due to carbicron treatment. 3. No alterations were observed in phospholipase A2 activity in the alveolar surfactant of intoxicated animals. The structural order parameter (SDPH) of bilayer liposomes, prepared from surfactant phospholipids of carbicron-treated rats also remained unchanged. |
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Authors:
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E Yanev; T Markovska; A Momchilova; R Pankov; T Sedloev; K Koumanov |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Volume: 103 ISSN: 0742-8413 ISO Abbreviation: Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-03-29 Completed Date: 1993-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310013 Medline TA: Comp Biochem Physiol C Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 553-5 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Medical Academy, Sofia, Bulgaria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / antagonists & inhibitors, metabolism Fluorescence Polarization Insecticides / toxicity* Male Organophosphorus Compounds / toxicity* Phospholipases A / drug effects, metabolism Phospholipases A2 Phospholipids / metabolism Pulmonary Alveoli / drug effects*, enzymology, metabolism Pulmonary Surfactants / drug effects*, metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Insecticides; 0/Organophosphorus Compounds; 0/Phospholipids; 0/Pulmonary Surfactants; 0/lipid transfer protein; 3735-78-2/dicrotophos; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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