| Alterations in the proliferative response of T cells from aged and chimeric mice. | |
| | |
MedLine Citation:
|
PMID: 2953684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Factors involved in the nonspecific and specific proliferative responses of T cells were examined in the A/J strain of mice that were physiologically aged in the specific pathogen-free condition. In aged A/J mice, the production of IL-1 and IL-2 from optimally stimulated peritoneal macrophages and splenic T cells was significantly decreased, while the production of IL-3 by T cells was increased. T cells from old mice showed a higher threshold for concanavalin A stimulation for the induction of IL-2 receptors. The same T cells responded only slightly in the mixed lymphocyte reaction (MLR) stimulated by allogeneic class II antigens, while they showed a high background stimulation without stimulators. The addition of syngeneic accessory cells did not increase the proliferative response of T cells from aged animals. T cells from bone marrow chimeras constituted by transferring stem cells from young A/J into irradiated old B10.A mice (young A/J----old B10.A chimeras) showed a pattern very similar to that of old A/J T cells, whereas those from the old A/J----young B10.A chimeras exhibited a response pattern comparable to that of normal young A/J cells. These results indicated that the proliferative responses in aged animals are abnormal, partially due to the alterations in the interleukin cascade. Some changes are probably due to the effect of environment where T cells undergo early differentiation, because bone marrow stem cells from aged mice can generate T cells with normal functions when differentiated in the young environment. |
| | |
Authors:
|
M Iwashima; T Nakayama; M Kubo; Y Asano; T Tada |
Related Documents
:
|
2937064 - Autocrine growth inhibition of a cloned line of helper t cells. 21278234 - Pivotal advance: cd45rb glycosylation is specifically regulated during human peripheral... 3875424 - Functional comparison of recombinant interleukin 2 (il-2) with il-2-containing preparat... 21407224 - Specific recognition and inhibition of ewing tumour growth by antigen-specific allo-res... 23259064 - Clinical trials and treatment of atl. 10712944 - Lymphoid precursors. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International archives of allergy and applied immunology Volume: 83 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1987 |
Date Detail:
|
Created Date: 1987-07-15 Completed Date: 1987-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 129-37 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging* Animals Concanavalin A / pharmacology Interleukin-1 / biosynthesis Interleukin-2 / biosynthesis Interleukin-3 / biosynthesis Lymphocyte Activation Lymphocyte Culture Test, Mixed Major Histocompatibility Complex Mice Mice, Inbred A Radiation Chimera Receptors, Immunologic / metabolism Receptors, Interleukin-2 Spleen / physiology T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-3; 0/Receptors, Immunologic; 0/Receptors, Interleukin-2; 11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparin interferes with the biological effectiveness of atriopeptin.
Next Document: T cell activation surface markers and autologous mixed lymphocyte reaction do not differ in true and...