| Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in peripheral arterial disease. | |
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MedLine Citation:
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PMID: 9199268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concentrations of the major lipoprotein classes and of high density lipoprotein (HDL) subfractions in 63 male patients with arteriosclerosis of the lower limbs (claudication) were determined and compared with values from 63 healthy controls. The patients with peripheral arterial disease (PAD) had reduced levels of total HDL-cholesterol and HDL2b of large particle size, increased levels of small HDL3c particles and a high ratio of total plasma-cholesterol to HDL-cholesterol (coronary risk factor). The PAD patients, however, had lower levels of low density lipoprotein (LDL)-cholesterol but higher concentrations of very low density lipoprotein (VLDL)-cholesterol and plasma triglyceride than healthy subjects. This study therefore suggests that in PAD, the protective effect of HDL may be more important than the atherogenic effect of LDL. It further suggests that while HDL-cholesterol HDL2b and the ratio of total plasma-cholesterol to HDL-cholesterol may provide valid indices for identifying individuals at risk of PAD, other factors, such as LDL and total cholesterol, may not provide such an appropriate risk indicator. |
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Authors:
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B F Mowat; E R Skinner; H M Wilson; G C Leng; F G Fowkes; D Horrobin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Atherosclerosis Volume: 131 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-11 Completed Date: 1997-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: IRELAND |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, UK. d.mcb@aberdeen.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis Obliterans
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blood*,
etiology Cholesterol, HDL / blood Cholesterol, VLDL / blood Electrophoresis, Gel, Pulsed-Field Humans Leg / blood supply* Lipids / blood* Lipoproteins / blood Lipoproteins, HDL / blood Lipoproteins, HDL2 Male Middle Aged Risk Factors Smoking / adverse effects Ultracentrifugation |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, VLDL; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, HDL2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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