| Alterations in pancreatic B-, A- and D-cell populations following administration of corticosteroids. Immunocytochemical study in rats. | |
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MedLine Citation:
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PMID: 2686284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prednisolone was administered to two groups of rats for 2 or 4 weeks, respectively. A third group served for control. Serum glucose and insulin levels were measured, and changes in population size along with alterations in staining density of the intracellular granules in pancreatic B-, A- and D-cells were assessed. Two weeks of prednisolone treatment induced significant increases in the staining density of the intracellular granules of B- and D-cells as well as the population size of A-cells, while significant hyperglucosaemia and hyperinsulinaemia were observed. Four weeks of prednisolone administration induced significant increases in population size of B- and D-cells and significant decrease in the population size of A-cells, while hyperglucosaemia and hyperinsulinaemia were even greater. It is concluded that corticosteroids cause an increase in pancreatic B-cell activity and, eventually A-cell numerical atrophy by altering the glucose metabolism. The changes in activity of D-cells possibly reflect functional adaptation to increased B-cell activity. |
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Authors:
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O J Zoras; J S Vassilakis; E Xynos; C Kittas; E Neonakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zentralblatt für allgemeine Pathologie und pathologische Anatomie Volume: 135 ISSN: 0044-4030 ISO Abbreviation: Zentralbl Allg Pathol Publication Date: 1989 |
Date Detail:
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Created Date: 1989-12-26 Completed Date: 1989-12-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105593 Medline TA: Zentralbl Allg Pathol Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 667-73 Citation Subset: IM |
Affiliation:
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Surgical Department, Medical School, University of Crete. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Female Hyperinsulinism / chemically induced Immunohistochemistry Insulin / blood Islets of Langerhans / cytology, drug effects* Prednisolone / toxicity* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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