Document Detail

Alterations in opiate receptor binding in MPTP-induced hemiparkinsonian monkeys.
MedLine Citation:
PMID:  1652716     Owner:  NLM     Status:  MEDLINE    
Quantitative autoradiography was used to study [3H]naloxone binding in the striatum of normal monkeys and monkeys made hemiparkinsonian by the unilateral infusion of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The density of [3H]naloxone binding sites was significantly higher in the caudate and putamen on the MPTP-treated side of hemiparkinsonian monkeys, as compared with binding on the untreated side and in the striatum of normal monkeys. A more extensive patchy distribution of binding sites was evident throughout the striatum on the MPTP-treated side than seen in the striatum of the untreated side or in normal striatum.
L J Porrino; J J Viola; A M Crane; F E Pontieri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  127     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-02     Completed Date:  1991-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Corpus Striatum / metabolism*
Functional Laterality
Macaca mulatta
Naloxone / metabolism*
Parkinson Disease, Secondary / metabolism*
Receptors, Opioid / metabolism
Reg. No./Substance:
0/Receptors, Opioid; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 465-65-6/Naloxone

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