| Alterations in neutral amino acid transport across the blood-brain barrier in hepatic failure. | |
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MedLine Citation:
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PMID: 6635335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The accelerated transport of the blood neutral amino acids into the brain in encephalopathic patients with fulminant hepatitis and advanced liver cirrhosis was demonstrated not only by determining the cerebrospinal fluid (CSF) aminogram but also by calculating the predicted velocity of the amino acid transport through the blood-brain barrier. Significant elevation in CSF aromatic amino acid (AAA) and methionine levels was observed in the encephalopathic patients. Arousal from hepatic encephalopathy by drip infusion of a branched chain amino acid (BCAA)-enriched solution was obtained coincidentally with the elevated BCAA levels and diminished concentrations of AAA and methionine in CSF. These clinical observations were confirmed experimentally in rats treated with carbon tetrachloride (CCl4) and D-galactosamine by obtaining the elevation of neutral amino acid contents in the brain and the slight increase in the brain uptake index (BUI) of a radiolabeled amino acid. |
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Authors:
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A Watanabe; T Higashi; T Shiota; N Takei; T Sakata; M Fujiwara; H Nakatsukasa; M Kobayashi; H Nagashima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Volume: 183 ISSN: 0300-9130 ISO Abbreviation: Res Exp Med (Berl) Publication Date: 1983 |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324736 Medline TA: Res Exp Med (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 11-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Amino Acids, Branched-Chain / blood Animals Blood-Brain Barrier* Hepatic Encephalopathy / blood* Hepatitis / blood Hepatitis, Animal / blood Humans Kinetics Liver Cirrhosis / blood Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Branched-Chain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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