Document Detail

Alterations in molecular killing mechanisms: implications in skin disease.
MedLine Citation:
PMID:  11899138     Owner:  NLM     Status:  MEDLINE    
Cytolytic T lymphocytes exert two main specific molecular killing mechanisms against target cells, namely (i) they can synthesize and release soluble cytolytic factors, and (ii) they can express effector molecules that act as ligands of receptors expressed by target cells on the cell surface; by these two pathways cytolytic T lymphocytes kill several targets, e.g. cells infected with intracellular pathogens, cells transformed by malignancy and cells producing autoantibodies. This review investigates the contribution from alterations in these molecular killing mechanisms to the pathogenesis of cutaneous diseases. In fact, molecular components involved in such killing mechanisms are often altered or distorted in skin pathology, e.g. cutaneous viral infections, skin cancer, contact hypersensitivity and autoimmune diseases with cutaneous involvement. Treatments capable of repairing the molecular components operating in such killing mechanisms could presumably favour the resolution of these skin diseases.
G De Panfilis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-03-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  868-76     Citation Subset:  IM    
Department of Dermatology. University of Parma, Italy.
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MeSH Terms
Autoimmune Diseases / immunology
Cytotoxicity, Immunologic*
Cytotoxins / immunology
Dermatitis, Allergic Contact / immunology
Membrane Proteins / immunology
Skin Diseases / immunology*
Skin Diseases, Viral / immunology
Skin Neoplasms / immunology
T-Lymphocytes, Cytotoxic / immunology*
Reg. No./Substance:
0/Cytotoxins; 0/Membrane Proteins

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