| Alterations in lipid, carbohydrate and iron metabolism in patients with non-alcoholic steatohepatitis (NASH) and metabolic syndrome. | |
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MedLine Citation:
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PMID: 21570653 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: NASH (non-alcoholic steatohepatitis) is considered the hepatic manifestation of the metabolic syndrome (MS). We aimed to analyze lipid, carbohydrate, and iron metabolism in NASH. PATIENTS, METHODS: 37 patients with MS (17 M/20 F, 51+/-15years), elevated transaminases; 25 patients had histologically proven NASH (NAS score≥5), 12 patients had toxic background (nonNASH). 37 age, sex, BMI-matched healthy controls. Lipid variables, LDL-subfractions, iron, ferritin, transferrin (T), transferrin saturation (TS), and hepcidin (H) were measured in patients/controls. Oral glucose tolerance tests were performed. RESULTS: NASH patients with steatosis gr. 2 and 3 (>33% hepatic fat) had higher sd-LDL (mg/dl) concentrations than patients with steatosis gr. 1 (<33%) (p=0.002), nonNASH patients (p=0.03) and controls (p=0.001). Sd absolute (mg/dl) correlated directly with the steatosis grade only in patients with NASH and steatosis >33% (p=0.04). NASH-patients showed higher insulin, C-peptide and IRI values than nonNASH patients (p=0.034; 0.032; 0.04). H was increased in patients versus controls (p<0.001). H correlated with ferritin in MS-patients (p=0.01), correlated directly with sd-LDL (mg/dl) (p=0.017) and IRI (p<0.001) and indirectly with HDL (p=0.05) in NASH. No associations between hepatic inflammation/iron content on liver biopsy and variables of lipid metabolism were found but hepcidin correlated with hepatic inflammation in all patients and with NAS scores in NASH. CONCLUSIONS: NASH-patients show insulin resistance and increased sd-LDL subfractions, suggesting an atherogenic profile. The correlation of H with sd-LDL and IRI, without relation to hepatic iron content suggests a putative link between inflammation, carbohydrate and lipid metabolism in NASH. |
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Authors:
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Anca Zimmermann; Tim Zimmermann; Jörn Schattenberg; Sebastian Pöttgen; Johannes Lotz; Heidi Rossmann; Ralf Roeddiger; Stefan Biesterfeld; Hans-Christian Geiss; Marcus Schuchmann; Peter R Galle; Matthias M Weber |
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Publication Detail:
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Type: Journal Article Date: 2011-02-12 |
Journal Detail:
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Title: European journal of internal medicine Volume: 22 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 305-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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1st Medical Clinic, Dept. of Endocrinology and Metabolic Diseases, Johannes Gutenberg University of Mainz, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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