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Alterations in the hemostatic profiles of dogs with naturally occurring septic peritonitis.
MedLine Citation:
PMID:  23317011     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To characterize derangements in the hemostatic profiles of dogs with naturally occurring septic peritonitis and determine if such derangements were predictive of survival. DESIGN: Prospective, observational single cohort study. SETTING: University veterinary teaching hospital. ANIMALS: A total of 27 client-owned dogs with naturally occurring septic peritonitis. INTERVENTIONS: Standard treatment included fluid resuscitation, antimicrobial therapy, supportive care, and surgery provided at the discretion of the primary clinician. Blood was collected preoperatively and on days 1 and 3 postoperatively for platelet count, prothrombin time, activated partial thromboplastin time, D-dimer and fibrinogen concentrations, total protein C (PC) and antithrombin (AT) activities, and thromboelastography. MEASUREMENTS AND MAIN RESULTS: Sixteen of 27 (59%) dogs survived. Preoperative PC deficiency was identified in 10 of 11 (91%) nonsurvivors and 2 of 15 (13%) survivors. Preoperative AT deficiency was identified in 10 of 11 (91%) nonsurvivors and 14 of 15 (93%) survivors. Compared to survivors, nonsurvivors had lower mean preoperative PC (98 ± 24% versus 49 ± 26%; P < 0.001) and AT (53 ± 9% versus 32 ± 16%; P < 0.001) activities. Anticoagulant activities decreased on day 1 postoperatively. As a predictor of survival, preoperative PC activity of more than 60% achieved a sensitivity of 93% and specificity of 82%. Preoperative AT activity of more than 41.5% achieved a sensitivity of 100% and specificity of 82%. The maximum amplitude, α angle, and coagulation index from preoperative thromboelastograms of survivors were significantly greater (more hypercoagulable) than nonsurvivors (P < 0.01), with the maximum amplitude being the most specific predictor of survival (100%). CONCLUSIONS: Deficiencies of PC and AT and hypercoagulability appear to be consistent features of naturally occurring canine sepsis and may be useful prognostic indicators in canine septic peritonitis.
Authors:
Adrienne M Bentley; Philipp D Mayhew; William T N Culp; Cynthia M Otto
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)     Volume:  -     ISSN:  1476-4431     ISO Abbreviation:  J Vet Emerg Crit Care (San Antonio)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101152804     Medline TA:  J Vet Emerg Crit Care (San Antonio)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Veterinary Emergency and Critical Care Society 2013.
Affiliation:
From the Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, 19104.
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