Document Detail


Alterations in the extracellular matrix of the myocardium in essential hypertension.
MedLine Citation:
PMID:  8281955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension produces myocyte hypertrophy and increases the extracellular matrix. In order to determine the composition of the extracellular matrix we studied the hearts from 14 hypertensive patients by immunohistochemistry using antibodies against collagen I, III, IV and V, fibronectin, myoglobin, muscular specific actin, Factor VIII, CD 34 and vimentin. The myocardium showed a focal increase in fibronectin, collagen I and III and diffuse deposition of laminin, collagen IV and V. Cells positive for vimentin, Factor VIII and CD 34 were also increased, but with considerable variation from case to case. We found no relation between matrix variation and the degree of hypertension or the time elapsed from the beginning of the disease. We conclude that the main role of the matrix in hypertension may be remodelling of the heart so that it entraps muscle fibres and increases their contractility.
Authors:
F J Pardo Mindán; A Panizo
Related Documents :
17173945 - Arsenic methylation capability and hypertension risk in subjects living in arseniasis-h...
24338935 - Resistant hypertension optimal treatment trial: a randomized controlled trial.
10232545 - Hypertensive encephalopathy as a complication of hyperdynamic therapy for vasospasm: re...
11416635 - Secondary hypertension: detection and management for the primary care provider.
21895845 - Perspective: physiological role(s) of the vascular myogenic response.
1866215 - Troponin t expression in normal and pressure-loaded fetal sheep heart.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  14 Suppl J     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  12-4     Citation Subset:  IM    
Affiliation:
Department of Pathology, Clínica Universitaria, University of Navarra, Pamplona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Extracellular Matrix / chemistry*,  pathology
Extracellular Matrix Proteins / analysis*
Female
Fibrosis
Humans
Hypertension / pathology*
Male
Middle Aged
Myocardium / chemistry,  pathology*
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regional myocardial ischaemia and diastolic dysfunction in hypertensive heart disease.
Next Document:  Left ventricular hypertrophy in post-myocardial infarction left ventricular remodelling and in hyper...