| Alterations in downstream mediators involved in central control of eating behavior in obese adolescents submitted to a multidisciplinary therapy. | |
| | |
MedLine Citation:
|
PMID: 21856523 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone [α-MSH]), in obese adolescents. METHODS: A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15-19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, α-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks). RESULTS: At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p < .05). The multidisciplinary therapy decreased NPY and AgRP values and increased α-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy. CONCLUSIONS: We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents. |
| | |
Authors:
|
Wagner L Prado; Lila M Oyama; Mara C Lofrano-Prado; Aline de Piano; Sérgio G Stella; Cláudia M O Nascimento; June Carnier; Danielle A Caranti; Lian Tock; Sérgio Tufik; Marco Túlio de Mello; Ana R Dâmaso |
Related Documents
:
|
15671233 - Vitamin d intake: a global perspective of current status. 18608563 - Spectroscopic investigation of the seeds of chilli (capsicum annum l.). 8295943 - Food deprivation- vs. intraventricular adrenaline-induced feeding and postprandial beha... |
Publication Detail:
|
Type: Journal Article Date: 2011-04-22 |
Journal Detail:
|
Title: The Journal of adolescent health : official publication of the Society for Adolescent Medicine Volume: 49 ISSN: 1879-1972 ISO Abbreviation: J Adolesc Health Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102136 Medline TA: J Adolesc Health Country: United States |
Other Details:
|
Languages: eng Pagination: 300-5 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Nutrition Postgraduate Program, Federal University of São Paulo/Paulista Medicine School, São Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peer relational victimization and somatic complaints during adolescence.
Next Document: Longitudinal and secular trends in parental encouragement for healthy eating, physical activity, and...