Document Detail


Alterations in cortical activity of male methamphetamine abusers performing an empathy task: fMRI study.
MedLine Citation:
PMID:  20041477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We investigate possible differences in neural correlates of empathy processing between abstinent methamphetamine (MA) abusers and healthy subjects using functional magnetic resonance imaging (fMRI). METHODS: Nineteen abstinent MA abusers (mean age of 36.06 years, range 31-52 years) and 19 healthy subjects (mean age of 37.05 years, range 33-42 years) participated in this study. A visual fMRI activation paradigm was used, comprising a series of cartoons, each depicting a short story. There were two categories of stories: empathy (Empathy) and Physical causality (Physical). fMRI images were acquired using a 3.0 T whole-body scanner. All fMRI data were analyzed using MATLAB v. 7.2 and SPM5. RESULTS: Both MA subjects and controls exhibited activation in the dorsomedial prefrontal cortex. Despite this similarity in activation patterns, we found that the two groups differed in the activation of several cortical regions associated with the processing of empathy information. Hypoactivations of the orbitofrontal cortex, temporal poles, and hippocampus in MA abusers relative to healthy subjects suggests that the ability of empathic response could be compromised in abstinent MA abusers (p < 0.05, corrected for a small volume). CONCLUSIONS: Functional impairments in the empathic neural network caused by MA may contribute to the misunderstanding of others and to the erosion of social interactions in MA abusers.
Authors:
Yang-Tae Kim; Jae-Jun Lee; Hui-Jin Song; Joo-Hyun Kim; Do-Hoon Kwon; Myoung-Nam Kim; Done-Sik Yoo; Hui Joong Lee; Hye-Jung Kim; Yongmin Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  25     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Bugok National Hospital, Gyeongsang nam-do, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amphetamine-Related Disorders / pathology*,  psychology*
Cerebral Cortex / blood supply*,  physiopathology*
Drug Users*
Empathy / physiology*
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen / blood
Personality Tests
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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