Document Detail

Alterations in conjunctival cytology and tear film dysfunction in patients with beta-thalassemia.
MedLine Citation:
PMID:  14508254     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Patients with beta-thalassemia (beta-tha) represent a group with lifelong transfusion-dependent anemias. This study aimed to describe the conjunctival changes and tear film parameters in these patients. METHODS: A total of 52 patients (104 eyes) with beta-tha major and 22 normal control subjects (44 eyes) were studied during 1999 through 2000. Tear film break-up time (BUT), Schirmer test, rose Bengal staining, and cytologic evaluation of the conjunctival epithelium were performed in all subjects. The Papanicolaou and May-Grümwald-Giemsa staining procedures were performed on all smears. Patients and control subjects were compared for tear function parameters and conjunctival changes. RESULTS: The BUT, Schirmer test, and rose Bengal staining values were significantly lower (P < 0.001) in beta-tha patients than in control subjects. Keratinized cells were observed in conjunctival samples in 41% of patients, with a decrease in the number of goblet cells per slide in 64% of patients. In 9% of beta-tha patients, there were a slightly greater number of inflammatory cells than in control eyes. CONCLUSION: Ocular surface disorder of these patients was characterized by goblet cell loss and conjunctival squamous metaplasia. Our findings were correlated positively with the variable age. Epithelial damage by toxic reaction and disorder of tear quality and quantity are implicated as important factors in the pathogenesis of the ocular surface disease in beta-tha patients.
S P Gartaganis; C D Georgakopoulos; A Exarchou; E K Mela; C Psachoulia; M I Eliopoulou; A Kourakli; S S Gotsis; R C Tripathi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cornea     Volume:  22     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-25     Completed Date:  2003-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
Department of Ophthalmmology, University of Patras Medical School, Patras, Grece.
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MeSH Terms
Cell Count
Conjunctiva / pathology*
Fluorescent Dyes / diagnostic use
Goblet Cells / pathology
Rose Bengal / diagnostic use
Staining and Labeling
Tears / metabolism*
beta-Thalassemia / metabolism*,  pathology*
Reg. No./Substance:
0/Fluorescent Dyes; 11121-48-5/Rose Bengal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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