Document Detail

Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids.
MedLine Citation:
PMID:  4441387     Owner:  NLM     Status:  MEDLINE    
2,4-Dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid inhibited the incorporation of [2-(14)C]mevalonate into cholesterol and non-saponifiable lipids. Both compounds inhibited the conversion of [1-(14)C]isopentenyl pyrophosphate into cholesterol and the synthesis of cholesterol and fatty acids from [2-(14)C]acetate. There was no inhibition of the conversion of [1-(14)C]mevalonate into CO(2). At low concentrations (0.5mm) of the compounds there was a stimulation of acetate incorporation into fatty acids.
R J Olson; T E Trumble; W Gamble
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  142     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1974 Aug 
Date Detail:
Created Date:  1975-03-18     Completed Date:  1975-03-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
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MeSH Terms
2,4,5-Trichlorophenoxyacetic Acid / pharmacology*
2,4-Dichlorophenoxyacetic Acid / pharmacology*
Acetates / metabolism
Carbon Radioisotopes
Cholesterol / biosynthesis*
Chromatography, Thin Layer
Fatty Acids / biosynthesis*
Liver / metabolism*
Mevalonic Acid / metabolism
Reg. No./Substance:
0/Acetates; 0/Carbon Radioisotopes; 0/Fatty Acids; 150-97-0/Mevalonic Acid; 57-88-5/Cholesterol; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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