| Alterations in cerebrospinal fluid PO(2), PCO(2), and pH measurements during and after experimental thoracic aortic cross-clamping. | |
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MedLine Citation:
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PMID: 18657389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a model of aortic cross-clamping, we studied the use of a multiparameter sensor for measurement of cerebrospinal fluid (CSF) PO(2), PCO(2), and pH during and after aortic cross-clamping. The present study addressed the above-mentioned alterations and their relation according to time intervals. In 31 pigs, a sensor was introduced into the intrathecal space and epidural laser Doppler was used to measure spinal cord blood flow (SCF). By placing the aortic clamp at different levels, three different spinal cord ischemia groups were obtained (mild, moderate, and severe). CSF variables with SCF were studied for 25%, 50%, and 100% changes according to baseline level. In the clamping period, SCF decreased 71.5%, 40.0%, and 33.3% in groups 1, 2, and 3, respectively. CSF O(2) tension reached 0 in group 1, decreased 74.8% in group 2, and was 12.7% in group 3. CSF CO(2) tension increased 247.2% and 202.0% in groups 1 and 2, respectively, but slightly increased in group 3. The maximum reaction time of CSF O(2) tension was about 16.7-26.9min, although this range was 34.5-49.8min in CSF CO(2) tension. We recognized that O(2) tension reacts faster than PCO(2) and pH. It is possible for O(2) tension to be used faster than produced CO(2) in the ischemic medium, although it is known that the diffusion rate of CO(2) is much higher. Spinal cord O(2) tension monitoring is an important method to detect ischemic changes. |
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Authors:
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Fatma Ulus; Anders Hellberg; A Tulga Ulus; Sadettin Karacagil |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-07-26 |
Journal Detail:
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Title: Annals of vascular surgery Volume: 23 ISSN: 1615-5947 ISO Abbreviation: Ann Vasc Surg Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-12 Completed Date: 2009-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Atatürk Training and Research Hospital for Chest Disease and Thoracic surgery, Ankara, Turkey. uluss@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / surgery Carbon Dioxide / cerebrospinal fluid* Constriction Disease Models, Animal Electrodes Female Fiber Optic Technology Hydrogen-Ion Concentration Laser-Doppler Flowmetry Male Monitoring, Physiologic* / instrumentation Oxygen / cerebrospinal fluid* Regional Blood Flow Spinal Cord / blood supply* Spinal Cord Ischemia / cerebrospinal fluid*, physiopathology, ultrasonography Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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