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Alterations in the cellular component of the maternal immune system in a murine preterm delivery model.
MedLine Citation:
PMID:  23311765     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Investigate changes in the cellular component of maternal immune system in a murine preterm delivery model. Methods: C57BL/6J mice were mated and on day 14.5 after plugging either whole blood was harvested or E.coli LPS was intraperitoneally injected. Preterm delivery resulted within 24hrs. 10-12hs after LPS injection (initiation of labour) whole blood was harvested. Annexin-V, CD3, CD4, CD8, CD80 and CD86 were counted after running through flow cytometer with gating for mononuclear cells. Control group consisted of non-pregnant mice. Results: Rate of apoptosis of monocytes and lymphocytes and expression of CD80(+) and CD86(+) was increased in non-pregnant mice after LPS injection (p=0.009, p=0.002, p<0.001 and p=0.005 respectively), but remained unaltered in pregnant mice. Expression of CD3(+)/4(+ )and CD3(+)/8(+ )on lymphocytes was increased after LPS injection in both pregnant (p=0.001, p=0.011 respectively) and non-pregnant mice (p=0.008, p<0.001 respectively). Conclusions: Cellular component of maternal non-specific immune system is remain suppressed in pregnant mice, whereas specific immune responses of pregnant mice to infection are similar to these of non-pregnant mice.
Authors:
Nikolaos E Evangelinakis; Elektra N Polyzou; George E Salamalekis; Lect Antigoni J Kotsaki; Charalampos G Chrelias; Evangelos J Giamarellos-Bourboulis; Demetrios P Kassanos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
3rd Department of Obstetrics & Gynecology, Medical School of Athens, General University Hospital "Attikon", Chaidari, Greece, P.C. 12461.
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