Document Detail

Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy.
MedLine Citation:
PMID:  16489598     Owner:  NLM     Status:  MEDLINE    
Maternal intrauterine inflammation during pregnancy poses a major threat of neurodevelopmental brain damage in offspring and may cause poor cognitive and perceptual outcomes. In mice, we have previously shown that maternal inflammation induced by lipopolysaccharide (LPS) at gestation day 17th increased the levels of the pro-inflammatory cytokine IL-6 in the fetal brain. In this study, we used the same system and examined the effect of short, systemic maternal inflammation on anxiety and social behavior of the offspring. Adult offspring from the maternal inflammation group showed increased anxiety, as indicated by the elevated plus maze. Social interaction among offspring from the test groups was examined when two unfamiliar mice from different litters were introduced into a new home-cage. Offspring from the maternal inflammation group showed reduced activity, indicating increased fear. In addition, offspring from the maternal inflammation group were less aggressive towards their cagemates and they spent a significantly longer time trimming the whiskers of their cagemates during the first 30 min of their interaction, compared to offspring from the control group. Our data suggest that short systemic maternal inflammation have long-lasting consequences on the adult mouse stress and social behavior.
Golan Hava; Lev Vered; Mazar Yael; Hallak Mordechai; Huleihel Mahoud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental psychobiology     Volume:  48     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-23     Completed Date:  2006-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley Periodicals, Inc. Dev Psychobiol 48: 162-168, 2006.
Department of Developmental Molecular Genetics and Zlotowski Center for Neuroscience Ben-Gurion University of the Negev Beer-Sheva, Israel.
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MeSH Terms
Age Factors
Arousal / physiology*
Brain / immunology
Escherichia coli / immunology*
Exploratory Behavior / physiology
Fear / physiology*
Gestational Age
Interleukin-6 / blood*
Lipopolysaccharides / immunology*
Maternal-Fetal Exchange / immunology*
Maze Learning / physiology
Mice, Inbred C57BL
Motor Activity / physiology
Prenatal Exposure Delayed Effects*
Social Behavior*
Spleen / immunology
Reg. No./Substance:
0/Interleukin-6; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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