| Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals. | |
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MedLine Citation:
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PMID: 20706676 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50-125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52 +/- 11 to 40 +/- 7 mg/dL) (P < .001). The mean LDL (P = .316), triglyceride (P = .910), and total cholesterol (P = .769) levels remained unchanged. In a subset of subjects, we measured serum leptin levels which were reduced by 25% but did not reach statistical significance (P = .181) while resistin levels remained unchanged. We conclude that testosterone therapy in FTM transsexuals can promote an increased atherogenic lipid profile by lowering HDL and possibly reduce serum leptin levels. However, long-term studies are needed to determine whether decreases in HDL result in adverse cardiovascular outcomes. |
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Authors:
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Prakash Chandra; Sukhdeep S Basra; Tai C Chen; Vin Tangpricha |
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Publication Detail:
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Type: Journal Article Date: 2010-07-18 |
Journal Detail:
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Title: International journal of endocrinology Volume: 2010 ISSN: 1687-8345 ISO Abbreviation: Int J Endocrinol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101516376 Medline TA: Int J Endocrinol Country: Egypt |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Woodruff Memorial Research Building, Room 1301, 101 Woodruff Circle NE, Atlanta, GA 30322, USA. |
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