Document Detail


Alterations in Inflammatory, Antiviral and Regulatory Cytokine Responses in Peripheral Blood Mononuclear Cells from Pregnant Women with Asthma.
MedLine Citation:
PMID:  23421904     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND & OBJECTIVE: Severe asthma exacerbations during pregnancy are a common complication leading to poor health outcomes for both mother and baby. Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregnancy: the balance may be altered by asthma and respiratory virus infection. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from (1) non-pregnant healthy controls, (2) pregnant non-asthmatics, (3) postpartum non-asthmatics, (4) non-pregnant asthmatics (5) pregnant asthmatics, and (6) postpartum asthmatics. Cells were cultured in vitro with the mitogen phytohaemagglutinin or with a strain of the 2009 pandemic swine influenza. Interferon-γ, interleukin-10, and interleukin-17 protein were measured from culture supernatant. Neutrophil counts were obtained in samples from pregnant and postpartum women. RESULTS: Following phytohaemagglutinin stimulation of peripheral blood mononuclear cells, pregnant asthmatics had significantly higher IL17 and significantly lower IFNγ responses compared to healthy non-pregnant women. Following infection with influenza, a significant reduction was also observed in interferon-γ and interleukin-10 production from PBMCs of pregnant asthmatics. The interleukin-17 response to phytohaemagglutinin correlated with the neutrophil percentage. Differences in interferon-γ interleukin-10 and interleukin-17 were found to persist for at least 6 months postpartum. CONCLUSIONS: A reduction in anti-viral and regulatory immunity with increased inflammation during pregnancy occurs in peripheral blood mononuclear cells from pregnant women with asthma. This novel information may relate to the increased susceptibility and disease severity to respiratory virus infections observed during pregnancy.
Authors:
Rebecca L Vanders; Peter G Gibson; Peter A B Wark; Vanessa E Murphy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-20
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.
Affiliation:
Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia.
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