Document Detail

Alterations in the host defense properties of human milk following prolonged storage or pasteurization.
MedLine Citation:
PMID:  20639776     Owner:  NLM     Status:  In-Process    
OBJECTIVES: Preterm infants are often fed pasteurized donor milk or mother's milk that has been stored frozen for up to 4 weeks. Our objectives were to assess the impact of pasteurization or prolonged storage at -20 degrees C on the immunologic components of human milk and the capability of the different forms of human milk to support bacterial proliferation.
MATERIALS AND METHODS: The concentrations and activities of major host defense proteins in the whey fractions of mother's milk stored for 4 weeks at -20 degrees C or pasteurized human donor milk were compared with freshly expressed human milk. Proliferation of bacteria incubated in the 3 forms of human milk was assessed.
RESULTS: Relative to freshly expressed human milk, the concentrations of lysozyme, lactoferrin, lactoperoxidase, and secretory immunoglobulin A were reduced 50% to 82% in pasteurized donor milk and the activities of lysozyme and lactoperoxidase were 74% to 88% lower (P < 0.01). Proliferation of bacterial pathogens in pasteurized donor milk was enhanced 1.8- to 4.6-fold compared with fresh or frozen human milk (P < 0.01).
CONCLUSIONS: The immunomodulatory proteins in human milk are reduced by pasteurization and, to a lesser extent, by frozen storage, resulting in decreased antibacterial capability. Stringent procedure to minimize bacterial contamination is essential during handling of pasteurized milk.
Henry Akinbi; Jareen Meinzen-Derr; Christine Auer; Yan Ma; Derek Pullum; Ryosuke Kusano; Krzysztof J Reszka; Kira Zimmerly
Related Documents :
6176606 - Excretion rates of antibiotics in milk of sheep and their effect on yogurt production.
7356016 - Prolactin in human milk: correlation with lactose, total protein, and alpha-lactalbumin...
6768406 - A mechanism for the chymosin-induced flocculation of casein micelles.
18010076 - The milk industry and the war.
16569076 - Digestive stability, micellarization, and uptake of beta-carotene isomers by caco-2 hum...
11984426 - Food safety: bovine spongiform encephalopathy (mad cow disease).
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  51     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center,Cincinnati, OH, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Increased number of regulatory T cells in children with eosinophilic esophagitis.
Next Document:  Antibiotic-associated bloody diarrhea in infants: clinical, endoscopic, and histopathologic profiles...