| Alterations in the Expression of the Anti-Apoptotic Factor HAX-1 upon Seizures-Induced Hippocampal Injury in the Neonatal Rat Brain. | |
| | |
MedLine Citation:
|
PMID: 21909957 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
HS1-associated protein X1 (HAX-1) is a mitochondrial protein which interacts with a diverse group of molecules such as inflammatory cytokines; interleukin-1, hematopoietic lineage specific protein-1 and vimentin. It has been reported that HAX-1 may act as antiapoptotic protein in HeLa- and Jurkat cells after Fas-treatment, irradiation or serum deprivation. This underlines the evidence that HAX-1 might be involved in both receptor- and mitochondria-mediated apoptosis pathways. However, the role of HAX-1 in neuronal death induced by status epilepticus in the immature brain has not been reported. In this study, we performed a status epilepticus in rats and investigated the dynamic changes of HAX-1 expression, HtrA2 distribution and caspase-3 activation in the hippocampus. Western blot and immunohistochemistry analysis revealed that HAX-1 was expressed at very low levels in the hippocampus. Status epilepticus in the immature brain significantly induced increased cytosolic accumulation of HAX-1 in a biphasic manner, induced an upregulation of HtrA2 and enhanced caspase-3 activity in the selectively vulnerable hippocampal CA1-subfield. Taken together, these results suggested that HAX-1 is probably involved in the pathophysiology of cell death induced by epilepsy. |
| | |
Authors:
|
A Rami; M Kim; J Niquet; A Langhagen |
Related Documents
:
|
17888417 - Estrogen deficiency, t cells and bone loss. 11934647 - Effects of prostaglandin e2 on gene expression in primary osteoblastic cells from prost... 2288647 - Detection of immunoregulatory lipid-like factors in human amniotic fluid. 15777737 - Regulatory roles and molecular signaling of tnf family members in osteoclasts. 9236857 - Immune stimulation--a class effect of phosphorothioate oligodeoxynucleotides in rodents. 17888627 - Innate and adaptive immune response to apoptotic cells. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-11 |
Journal Detail:
|
Title: Neurochemical research Volume: - ISSN: 1573-6903 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institut für Zelluläre und Molekulare Anatomie (Anatomie III), Klinikum der Johann Wolfgang von Goethe-Universität, Theodor-Stern-Kai 7, 60590, Franfurt/Main, Germany, Rami@em.uni-frankfurt.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal Depression Model: Long-Lasting Effects on the Mother Following Separation from Pups.
Next Document: Protection by DHA of Early Hippocampal Changes in Diabetes: Possible Role of CREB and NF-?B.