| Alterations in cerebral metabolic rate and blood supply across the adult lifespan. | |
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MedLine Citation:
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PMID: 21051551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With age, the brain undergoes comprehensive changes in its function and physiology. Cerebral metabolism and blood supply are among the key physiologic processes supporting the daily function of the brain and may play an important role in age-related cognitive decline. Using MRI, it is now possible to make quantitative assessment of these parameters in a noninvasive manner. In the present study, we concurrently measured cerebral metabolic rate of oxygen (CMRO(2)), cerebral blood flow (CBF), and venous blood oxygenation in a well-characterized healthy adult cohort from 20 to 89 years old (N = 232). Our data showed that CMRO(2) increased significantly with age, while CBF decreased with age. This combination of higher demand and diminished supply resulted in a reduction of venous blood oxygenation with age. Regional CBF was also determined, and it was found that the spatial pattern of CBF decline was heterogeneous across the brain with prefrontal cortex, insular cortex, and caudate being the most affected regions. Aside from the resting state parameters, the blood vessels' ability to dilate, measured by cerebrovascular reactivity to 5% CO(2) inhalation, was assessed and was reduced with age, the extent of which was more prominent than that of the resting state CBF. |
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Authors:
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Hanzhang Lu; Feng Xu; Karen M Rodrigue; Kristen M Kennedy; Yamei Cheng; Blair Flicker; Andrew C Hebrank; Jinsoo Uh; Denise C Park |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-04 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 21 ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-20 Completed Date: 2011-09-13 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 1426-34 Citation Subset: IM |
Affiliation:
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Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. hanzhang.lu@utsouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Cerebral Cortex / blood supply, metabolism* Cerebrovascular Circulation / physiology* Energy Metabolism / physiology* Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Middle Aged Oxygen / blood Oxygen Consumption / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG033106/AG/NIA NIH HHS; R01 MH084021/MH/NIMH NIH HHS; R21 AG034318/AG/NIA NIH HHS; R37 AG006265/AG/NIA NIH HHS; R37 AG006265/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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