| Alterations in C3, C4, factor B, and related metabolites in septic shock. | |
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MedLine Citation:
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PMID: 8403550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty subjects consisting of (i) patients with septic shock, (ii) patients with sepsis without shock, (iii) critically ill non-septic patients, and (iv) normal controls were studied for plasma C3, C4, factor B, iC3b, C4d, Bb, and SC5b-9 levels in an attempt to profile the pattern of complement activation in sepsis. Significant decreases in plasma C3 and C4 concentrations were observed in septic shock patients compared to normal as well as to critically ill subjects. When adjusted for illness severity, levels of C3 but not C4 showed significant differences between septic shock and critically ill patients. Concentrations of the complement metabolite Bb as well as the Bb to factor B ratio were significantly increased in septic shock patients. SC5b-9 levels were significantly higher in septic shock patients compared to normal as well as to critically ill subjects. No increases in C4d or iC3b were observed, but the iC3b to C3 ratio was higher in septic shock patients compared to that in normal subjects. In septic shock patients, there were significant correlations between SC5b-9 and Bb (P = 0.0213) concentrations and between C3 and Factor B concentrations (P = 0.0041). SC5b-9 levels also were correlated with lactate levels in septic shock patients (P = 0.0091). These findings demonstrate a metabolite pattern consistent with primarily alternative and terminal pathway activation in septic shock patients. Decreases in C4, a classical pathway component, may not be specific for septic shock and do not appear to be necessarily due to significant complement consumption/activation. |
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Authors:
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R Y Lin; M E Astiz; J C Saxon; D C Saha; E C Rackow |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 69 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-18 Completed Date: 1993-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 136-42 Citation Subset: IM |
Affiliation:
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Department of Medicine, St. Vincent's Hospital, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Bacterial Infections / immunology Complement Activation Complement C3 / analysis*, metabolism Complement C3b / analysis Complement C4 / analysis Complement C4b* Complement Factor B / analysis*, metabolism Complement Membrane Attack Complex / metabolism Humans Middle Aged Peptide Fragments / analysis Shock / immunology Shock, Septic / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C4; 0/Complement Membrane Attack Complex; 0/Peptide Fragments; 80295-43-8/Complement C3b; 80295-50-7/Complement C4b; 80295-52-9/complement C4d; EC 3.4.21.47/Complement Factor B |
| Comments/Corrections | |
Comment In:
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Clin Immunol Immunopathol. 1994 Jul;72(1):150-1
[PMID:
8020189
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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