Document Detail


Alterations of granulopoiesis in chronic uremic patients treated with intermittent hemodialysis.
MedLine Citation:
PMID:  3115033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocyte-macrophage progenitor cells (CFU-GM), leukocyte colony-stimulating activity (CSA), granuloblast differentiation and proliferation and the effect of uremic serum on the in vitro growth of normal CFU-GM have been studied in 8 chronic uremic patients treated with intermittent hemodialysis three times a week. The studies were performed in the postabsorptive state twice in each patient, that is at the longest and shortest dialytic interval. CFU-GM growth in agar and leukocyte CSA did not differ significantly from the normal level in uremic subjects. The granulocytic and macrophagic differentiation in a liquid culture system was significantly reduced in uremic patients, notwithstanding the appearance of high numbers of undifferentiated blastic cells. The serum of uremic patients had no effect on normal CFU-GM and leukocyte CSA.
Authors:
A Ponassi; L Morra; G Gurreri; F Moccia; M Giusti; G Caristo; C Sacchetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  77     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-13     Completed Date:  1987-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cell Differentiation
Cell Division
Chronic Disease
Colony-Stimulating Factors / metabolism
Female
Granulocytes / pathology,  physiology*
Hematopoiesis
Humans
Leukocytes / metabolism
Macrophages / pathology,  physiology
Male
Middle Aged
Renal Dialysis*
Stem Cells / pathology
Uremia / blood,  pathology,  therapy*
Chemical
Reg. No./Substance:
0/Colony-Stimulating Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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