Document Detail


Alterations of gastrointestinal motility in obesity.
MedLine Citation:
PMID:  15601965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
All nutrients are absorbed in the gastrointestinal (GI) system, and GI motility plays a very critical role in the consumption of foods, digestion, and absorption of nutrients. Various segments of the GI tract (esophagus, stomach, and intestines) coordinate in a complex yet precise way to control the process of food consumption, digestion, and absorption of nutrients. GI motility not only regulates the rates at which nutrients are processed and absorbed in the gut but also participates in the control of appetite and satiety. Altered GI motility has been associated with various disease conditions (gastroparesis, etc.) and has been frequently observed in obese patients. The significance of these GI motility alterations in obesity is not fully understood, but they have been considered as potential contributing factors in the development and maintenance of obesity and changed eating behavior. Therapies aimed at regulating GI motility are being actively explored and applied clinically for the management of obese patients. To better understand the pathophysiology of obesity, we systematically reviewed GI motility changes observed in obese conditions. The relationship and pathological significance of these findings, as well as the potential therapies by modification of GI motility, are also discussed.
Authors:
Jinhong Xing; Jiande D Z Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Obesity research     Volume:  12     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2005-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1723-32     Citation Subset:  IM    
Affiliation:
Veterans Research Foundation and Transneuronix Inc., Oklahoma City, Oklahoma, USA.
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MeSH Terms
Descriptor/Qualifier:
Colon / physiopathology
Eating
Gastric Emptying / physiology
Gastroesophageal Reflux / complications,  epidemiology,  physiopathology
Gastrointestinal Motility / physiology*
Humans
Intestine, Small / physiopathology
Obesity / complications,  physiopathology*
Stomach / innervation,  physiopathology
Grant Support
ID/Acronym/Agency:
1R43-DK063733-01/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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