Document Detail


Alterations of the central noradrenergic system in MPTP-induced monkey parkinsonism.
MedLine Citation:
PMID:  2849789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alterations of the coeruleo-cortical adrenergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced monkey parkinsonism were examined through neuropathological observation and radioreceptor assay. Neuronal degeneration was found not only in the substantia nigra but also in the locus coeruleus of all the MPTP-treated monkeys. From radioreceptor assay, decreases of alpha 1 and alpha 2 receptors in the parietal and temporal cortices were observed in parkinsonian monkeys. In addition, beta receptors increased in the temporal cortex. These changes in monkey parkinsonism are very similar to those in human Parkinson's disease.
Authors:
R Miyoshi; S Kito; H Ishida; S Katayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  62     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Binding Sites
Brain / pathology*
Brain Chemistry
Female
Haplorhini
Locus Coeruleus / analysis,  pathology
Male
Nerve Degeneration
Parietal Lobe / analysis
Parkinson Disease, Secondary / chemically induced*,  metabolism,  pathology
Pyridines / pharmacology*
Receptors, Adrenergic, alpha / analysis*
Receptors, Adrenergic, beta / analysis*
Substantia Nigra / analysis,  pathology
Temporal Lobe / analysis
Chemical
Reg. No./Substance:
0/Pyridines; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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