Document Detail

Alterations of the central noradrenergic system in MPTP-induced monkey parkinsonism.
MedLine Citation:
PMID:  2849789     Owner:  NLM     Status:  MEDLINE    
Alterations of the coeruleo-cortical adrenergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced monkey parkinsonism were examined through neuropathological observation and radioreceptor assay. Neuronal degeneration was found not only in the substantia nigra but also in the locus coeruleus of all the MPTP-treated monkeys. From radioreceptor assay, decreases of alpha 1 and alpha 2 receptors in the parietal and temporal cortices were observed in parkinsonian monkeys. In addition, beta receptors increased in the temporal cortex. These changes in monkey parkinsonism are very similar to those in human Parkinson's disease.
R Miyoshi; S Kito; H Ishida; S Katayama
Related Documents :
22772839 - Thumbs up sign in brain death.
19855389 - Frontal eye field neurons signal changes in decision criteria.
7415849 - Functional properties of neurones in the parietal retroinsular cortex in awake monkey.
2849789 - Alterations of the central noradrenergic system in mptp-induced monkey parkinsonism.
17786549 - Immunohistochemical and biochemical analyses of lgi3 in monkey brain: lgi3 accumulates ...
22443509 - Mechanisms of gamma oscillations.
24121129 - Rumination mediates the relationship between structural variations in ventrolateral pre...
19717679 - Buccal neurons activate ciliary beating in the foregut of the pteropod mollusk clione l...
17442499 - Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in hu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  62     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Binding Sites
Brain / pathology*
Brain Chemistry
Locus Coeruleus / analysis,  pathology
Nerve Degeneration
Parietal Lobe / analysis
Parkinson Disease, Secondary / chemically induced*,  metabolism,  pathology
Pyridines / pharmacology*
Receptors, Adrenergic, alpha / analysis*
Receptors, Adrenergic, beta / analysis*
Substantia Nigra / analysis,  pathology
Temporal Lobe / analysis
Reg. No./Substance:
0/Pyridines; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of vascular Na,K-ATPase activity in salt induced hypertension in Dahl rats.
Next Document:  Myocardial perfusion pressure: a predictor of 24-hour survival during prolonged cardiac arrest in do...