| Alterations of the central noradrenergic system in MPTP-induced monkey parkinsonism. | |
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MedLine Citation:
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PMID: 2849789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alterations of the coeruleo-cortical adrenergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced monkey parkinsonism were examined through neuropathological observation and radioreceptor assay. Neuronal degeneration was found not only in the substantia nigra but also in the locus coeruleus of all the MPTP-treated monkeys. From radioreceptor assay, decreases of alpha 1 and alpha 2 receptors in the parietal and temporal cortices were observed in parkinsonian monkeys. In addition, beta receptors increased in the temporal cortex. These changes in monkey parkinsonism are very similar to those in human Parkinson's disease. |
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Authors:
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R Miyoshi; S Kito; H Ishida; S Katayama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 62 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-02-09 Completed Date: 1989-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-102 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Binding Sites Brain / pathology* Brain Chemistry Female Haplorhini Locus Coeruleus / analysis, pathology Male Nerve Degeneration Parietal Lobe / analysis Parkinson Disease, Secondary / chemically induced*, metabolism, pathology Pyridines / pharmacology* Receptors, Adrenergic, alpha / analysis* Receptors, Adrenergic, beta / analysis* Substantia Nigra / analysis, pathology Temporal Lobe / analysis |
| Chemical | |
Reg. No./Substance:
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0/Pyridines; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
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