Document Detail


Alterations of cell-mediated immune response in children with febrile seizures.
MedLine Citation:
PMID:  9629377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present investigation was to study the distribution of T-cell subsets in peripheral blood defined by monoclonal antibodies and by the lymphocyte proliferative response to phytohemagglutinin (PHA) in 30 children with febrile seizures and in 14 age-matched control subjects. Frequent respiratory, urinary and dermatologic infections were observed in 22 patients. The immunologic parameters showed that 64% of the patients presented an increased number of CD8+ cells and a low helper/suppressor ratio was observed in 60% of the patients. In addition, the proliferative response of lymphocytes to PHA was impaired in the patients. It was observed the presence of inhibitory activity on lymphocyte function in the plasma of 33% of children with febrile seizures. These results suggest that patients with febrile seizures have an impairment of cellular immunity that may be connected with this epileptic syndrome and explain the infections observed.
Authors:
T C Montelli; A M Soares; M R Parise-Fortes; M T Rezkallah-Iwasso; N M Padula; M T Peraçoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  55     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1998-09-08     Completed Date:  1998-09-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM; X    
Affiliation:
Department of Neurology and Psychiatry, School of Medicine, State University of São Paulo (UNESP), Botcatu, Brazil.
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MeSH Terms
Descriptor/Qualifier:
CD4-CD8 Ratio
Child, Preschool
Female
Follow-Up Studies
Humans
Immunoglobulin G
Infant
Male
Phytohemagglutinins / diagnostic use
Prospective Studies
Seizures, Febrile / blood*,  immunology*
T-Lymphocyte Subsets / immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Phytohemagglutinins; 0/phytohemagglutinin-P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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