| Alterations by peroxisome proliferators of acyl composition of hepatic phosphatidylcholine in rats, mice and guinea-pigs. Role of stearoyl-CoA desaturase. | |
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MedLine Citation:
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PMID: 2874791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats, mice and guinea-pigs were administered p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2'-(decamethylenedithio)diethanol (tiadenol). The treatments of rats and mice with either clofibric acid or tiadenol increased markedly the activities of stearoyl-CoA desaturase, palmitoyl-CoA chain elongation, 1-acylglycerophosphate (1-acyl-GP) acyltransferase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, but not 2-acylglycerophosphocholine (2-acyl-GPC) acyltransferase in liver microsomes. The treatment of guinea-pigs with clofibric acid did not cause any change in the activities of these enzymes. The treatment of guinea-pigs with tiadenol caused a slight, but significant, increase in the activities of 1-acyl-GP acyltransferase and 1-acyl-GPC acyltransferase. The treatment of rats and mice with either clofibric acid or tiadenol increased markedly the proportion of 18:1 and decreased greatly the proportion of 18:0 in liver microsomal phosphatidylcholine. However, there is a considerable difference in the effects of the two peroxisome proliferators on the composition of polyunsaturated fatty acids in phosphatidylcholine between rats and mice. The treatment of guinea-pigs with either of the two peroxisome proliferators caused no change in acyl composition of phosphatidylcholine. The possible role of stearoyl-CoA desaturation in the regulation of acyl composition of phosphatidylcholine was discussed. |
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Authors:
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Y Kawashima; A Hirose; H Kozuka |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 235 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 251-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism Acyltransferases / metabolism Animals Clofibrate / analogs & derivatives* Clofibric Acid / pharmacology* Fatty Acid Desaturases / metabolism* Fatty Alcohols / pharmacology* Guinea Pigs Liver / drug effects, metabolism* Mice Microbodies / drug effects Microsomes, Liver / enzymology Palmitoyl Coenzyme A / metabolism Phosphatidylcholines / metabolism* Rats Rats, Inbred Strains Species Specificity Stearoyl-CoA Desaturase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Fatty Alcohols; 0/Phosphatidylcholines; 1763-10-6/Palmitoyl Coenzyme A; 362-66-3/stearoyl-coenzyme A; 637-07-0/Clofibrate; 6964-20-1/tiadenol; 882-09-7/Clofibric Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 2.3.-/Acyltransferases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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