Document Detail


Alterations by peroxisome proliferators of acyl composition of hepatic phosphatidylcholine in rats, mice and guinea-pigs. Role of stearoyl-CoA desaturase.
MedLine Citation:
PMID:  2874791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats, mice and guinea-pigs were administered p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2'-(decamethylenedithio)diethanol (tiadenol). The treatments of rats and mice with either clofibric acid or tiadenol increased markedly the activities of stearoyl-CoA desaturase, palmitoyl-CoA chain elongation, 1-acylglycerophosphate (1-acyl-GP) acyltransferase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, but not 2-acylglycerophosphocholine (2-acyl-GPC) acyltransferase in liver microsomes. The treatment of guinea-pigs with clofibric acid did not cause any change in the activities of these enzymes. The treatment of guinea-pigs with tiadenol caused a slight, but significant, increase in the activities of 1-acyl-GP acyltransferase and 1-acyl-GPC acyltransferase. The treatment of rats and mice with either clofibric acid or tiadenol increased markedly the proportion of 18:1 and decreased greatly the proportion of 18:0 in liver microsomal phosphatidylcholine. However, there is a considerable difference in the effects of the two peroxisome proliferators on the composition of polyunsaturated fatty acids in phosphatidylcholine between rats and mice. The treatment of guinea-pigs with either of the two peroxisome proliferators caused no change in acyl composition of phosphatidylcholine. The possible role of stearoyl-CoA desaturation in the regulation of acyl composition of phosphatidylcholine was discussed.
Authors:
Y Kawashima; A Hirose; H Kozuka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  235     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  251-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / metabolism
Acyltransferases / metabolism
Animals
Clofibrate / analogs & derivatives*
Clofibric Acid / pharmacology*
Fatty Acid Desaturases / metabolism*
Fatty Alcohols / pharmacology*
Guinea Pigs
Liver / drug effects,  metabolism*
Mice
Microbodies / drug effects
Microsomes, Liver / enzymology
Palmitoyl Coenzyme A / metabolism
Phosphatidylcholines / metabolism*
Rats
Rats, Inbred Strains
Species Specificity
Stearoyl-CoA Desaturase / metabolism*
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Fatty Alcohols; 0/Phosphatidylcholines; 1763-10-6/Palmitoyl Coenzyme A; 362-66-3/stearoyl-coenzyme A; 637-07-0/Clofibrate; 6964-20-1/tiadenol; 882-09-7/Clofibric Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 2.3.-/Acyltransferases
Comments/Corrections

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