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Alterations of bone mineral metabolism of children with different cell lineage types of acute lymphoblastic leukaemia under chemotherapy.
MedLine Citation:
PMID:  21607035     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Children with haematological malignancies such as acute lymphoblastic leukaemia (ALL) may have alteration of bone mineral metabolism therefore increased risk for osteopenia and osteoporosis.
PATIENTS AND METHODS: The purpose of this study was to examine the alterations of bone mineral metabolism in two groups of children (n=42) according to immunophenotyping (B-cell type, T-cell type) both quantitative (bone mineral density z-scores) and qualitative (serum osteocalcin - OC and carboxyl-terminal telopeptide of human type I collagen - ICTP) during diagnosis (T=0), after the intensified chemotherapy period (T=0.5) and the consolidation period (T=1).
RESULTS: According to our results 15 patients had osteopenia and 1 child developed osteoporosis at T=0.5 and 13 patients had osteopenia at T=1. Mean BMD z-score was significantly decreased in both groups during chemotherapy and especially statistically significant decline of T-cell type ALL group compared with B-cell type ALL patients. OC mean level remains in low levels for both groups reaching in plateau during chemotherapy and ICTP level was increased in T-cell type ALL group of patients compared with B-cell type in both periods of chemotherapy.
CONCLUSIONS: It seems that not only the combination of chemotherapeutic agents but also the cell lineage of ALL are important parameters of altering bone mineral metabolism.
Authors:
A Tragiannidis; Ch Dokos; V Sidi; Th Papageorgiou; D Koliouskas; M Karamouzis; Ch Papastergiou; I Tsitouridis; G Katzos; I Rousso; F Athanassiadou-Piperopoulou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hippokratia     Volume:  15     ISSN:  1790-8019     ISO Abbreviation:  Hippokratia     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-05-24     Completed Date:  2011-07-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101296613     Medline TA:  Hippokratia     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  -    
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