Document Detail


Alterations of atrial natriuretic peptide in cardiomyocytes and plasma of rats after different intensity exercise.
MedLine Citation:
PMID:  17555537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To characterize the effect of long-term exercise training at different intensities on endocrine structure and function of the heart, plasma atrial natriuretic peptide (ANP) levels, expression of ANP in cardiomyocytes, and ultrastructure of cardiomyocytes were examined by radioimmunoassay, immunohistochemistry and transmission electron microscopy in Sprague-Dawley rats trained on a treadmill at different intensities for 8 weeks. The plasma ANP increased gradually with increasing exercise intensity. The immunoreactivity of ANP in cardiomyocytes increased in the moderate- and high-intensity exercise group and decreased in the exhaustive exercise group. The ANP electron-dense granules and the quantity and volume of mitochondria increased in moderate and high-intensity exercise group. The ANP electron dense granules decreased and the mitochondria tumefied in the exhaustive exercise group. The changes of plasma ANP have a tendency of increasing gradually with increase in exercise intensity. Moderate and high-intensity exercise increases ANP synthesis and storage in cardiomyocytes and induces adaptive changes in the ultrastructure of cardiomyocytes. The decrease of ANP immunoreactivity in cardiomyocytes after exhaustive exercise is probably the result of massive depletion and induces damaging changes in the ultrastructure of cardiomyocytes.
Authors:
S S Pan
Related Documents :
24119027 - Illness cognition as a predictor of exercise habits and participation in cardiac preven...
8290907 - Involvement of the renin angiotensin system in the pathogenesis of postexercise protein...
16159987 - Comparison of endothelial vasodilator function, inflammatory markers, and n-terminal pr...
19606057 - Usefulness of nt-probnp in the assessment of patients with aortic or mitral regurgitation.
11445757 - Effect of altitude training on the peroxidation and antioxidant enzymes in sportsmen.
6683607 - Failure of endurance training to alter the cardiovascular response to static contraction.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-06
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  18     ISSN:  0905-7188     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  346-53     Citation Subset:  IM    
Affiliation:
Department of Sports Anatomy, College of Exercise and Sport Science, Shanghai University of Sport, Shangai, China. panshanshan@yahoo.com.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / blood*,  metabolism*
Exercise Test
Immunohistochemistry
Male
Myocardium / chemistry*,  cytology
Myocytes, Cardiac / chemistry*
Physical Conditioning, Animal*
Rats
Rats, Sprague-Dawley
Time Factors
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice.
Next Document:  Prevalence and incidence of lower extremity injuries in male marathon runners.