| Alterations of acute phase reaction and cytokine production in patients following severe burn injury. | |
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MedLine Citation:
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PMID: 12220910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the acute immunologic reaction, mediated by cytokines, interleukines (ILs) and growth factors and the susceptibility to infections and sepsis after severe burn injury a prospective, single unit, longitudinal study of acute phase reactants and mediators who performed. After approval by the ethics committee of our hospital, we investigated the plasma concentrations of IL-2, -6, -8, -10, and -13, the soluble IL-2 receptor (sIL-2R), and the acute phase proteins procalcitonin (PCT) and C-reactive protein (CRP) at admission and every 3 days in 24 patients over a time course of 28 days after thermal injury and categorized by percent burn: < or =30% (group 1; n=12) and >30% (group 2; n=12). Shortly after burn injury we found higher concentrations of IL-2, -6, -10 and PCT in those patients >30% TBSA. During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. The incidence of SIRS and MODS was three times increased in patients >30% TBSA. Our results show different patterns of cytokines and acute phase proteins in patients with different burned surface areas over a long time and continuous monitoring of a more distinct inflammatory response in these patients. |
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Authors:
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Marius G Dehne; Armin Sablotzki; Andreas Hoffmann; Jörg Mühling; Friedrich E Dietrich; Gunter Hempelmann |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 28 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-10 Completed Date: 2003-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 535-42 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Strasse 7, Germany. marius.g.dehne@chiru.med.uni-giessen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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analysis Acute-Phase Reaction / blood* Adult Analysis of Variance Burns / blood* Calcitonin / blood Cytokines / biosynthesis*, blood Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Prospective Studies Protein Precursors / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Cytokines; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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