| Alterations of PI3K and Akt signaling pathways in the hippocampus and hypothalamus of Wistar rats treated with highly palatable food. | |
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MedLine Citation:
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PMID: 22305648 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Highly palatable food (HPF), which is enriched in simple sugars and saturated fat, contributes to obesity and insulin resistance in humans. These metabolic changes are associated with serious complications of the central nervous system, including an elevated risk of cognitive dysfunction. We, herein, treated rats with HPF and then examined the insulin-signaling pathway, in particular, the levels of phosphatidylinositol-3 kinase (PI3K), Akt, and insulin receptor substrate-1 (IRS-1) in the hippocampus and hypothalamus. METHODS: Adult Wistar rats fed with HPF (heated or not during preparation) for 4 months and then measured the levels of PI3K, Akt, and IRS-1 in the hippocampus and hypothalamus, by western blotting and quantitative real-time polymerase chain reaction. RESULTS: We observed changes in body weight, glucose intolerance, and lipidemia, confirming that peripheral metabolic alterations were induced using this model. Hippocampal PI3K and hypothalamic Akt were affected in rats that are submitted to chronic exposure to an HPF diet. Moreover, heated HPF caused differentiated alterations in the regulatory subunit of PI3K in the hippocampus. DISCUSSION: Our data suggest that this diet alters insulin signaling differentially in each brain region, and that hippocampal changes induced by this diet could contribute to the understanding of cognitive impairments that are dependent on the hippocampus. |
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Authors:
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Cíntia E Battú; Débora Rieger; Samanta Loureiro; Gabriel V Furtado; Hugo Bock; Maria-Luiza Saraiva-Pereira; Regina Pessoa-Pureur; Carlos-Alberto Gonçalves; Marcos-Luiz S Perry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutritional neuroscience Volume: 15 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 10-7 Citation Subset: IM |
Affiliation:
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Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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