Document Detail

Alterations of lipid metabolism in chronic nephropathies: mechanisms, diagnosis and treatment.
MedLine Citation:
PMID:  20357496     Owner:  NLM     Status:  MEDLINE    
Nephropathic subjects show an increased tendency to develop cardiovascular diseases, mainly as the consequence of several risk factors including increased oxidative stress, inflammation, physical inactivity, anemia, vascular calcification, and endothelial dysfunction. The alterations in lipid metabolism represent a relatively lesser important cause of genesis and progression of atherosclerosis. Unfortunately, in these patients the atherogenic potential of dyslipidemia may depend more on apolipoproteins than on lipid abnormalities, and may not always be recognized by measurement of plasma lipids alone. The aim of this review was therefore to analyze the main lipid alterations that can occur in nephropathic patients, as well as their causes and their effects on the cardiovascular system. The clinical evidence and recommendations for the use of lipid-regulating drugs in patients with chronic kidney disease, nephrotic syndrome, in patients undergoing hemo- and peritoneal dialysis and in transplanted patients was also reviewed. Moreover, we analyzed the link between dyslipidemia and kidney disease onset and progression and the role of statins in preventing it.
Antonio Lacquaniti; Davide Bolignano; Valentina Donato; Caterina Bono; Maria Rosaria Fazio; Michele Buemi
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-27
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  33     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  100-10     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Internal Medicine, University of Messina, Messina, Italy.
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MeSH Terms
Atherosclerosis / etiology
Chronic Disease
Dyslipidemias / complications,  etiology*
Kidney Diseases / complications,  diagnosis,  metabolism*,  therapy
Lipid Metabolism*

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