Document Detail

Alteration of serum soluble endoglin levels after the onset of preeclampsia is more pronounced in women with early-onset.
MedLine Citation:
PMID:  18971528     Owner:  NLM     Status:  MEDLINE    
It has been established that serum soluble endoglin (sEng) increases in women with preeclampsia. However, sEng levels have not been evaluated using a normal reference value specific to each gestational age. First, we established the normal reference value for sEng using 85 pregnant controls without preeclampsia, from whom serum samples were collected three times at 20-23, 27-30, and 36-38 weeks of gestation. Second, we evaluated the serum sEng levels after the onset of preeclampsia in 56 preeclamptic patients. In three women (3.5%) with normal pregnancies, sustained high sEng levels (>15 ng/mL) were observed. We calculated the reference value for sEng using the remaining 82 normal controls. The log10sEng was almost normally distributed at each gestational week during 20-38 weeks, and the mean log10sEng was represented as a quadratic curve of gestational week. The SD of log10sEng was represented as a linear equation of gestational week. The mean log10sEng significantly and gradually increased from 20-23 weeks to 27-30 weeks of gestation and then rapidly increased at 36-38 weeks of gestation. Ninety-three percent of preeclamptic women showed sEng>or=95th percentile of the reference value. The log10sEng levels and the SD score (SDS) of log10sEng in women with early-onset preeclampsia (onset<32 weeks of gestation) were significantly higher than those in women with late-onset preeclampsia (onset>or=32 weeks of gestation) (1.97+/-0.23 vs. 1.78+/-0.28, 9.94+/-2.61 vs. 4.47+/-2.06, respectively). In conclusion, alteration of serum sEng levels after the onset of preeclampsia was more pronounced in women with early-onset preeclampsia compared to those with late onset.
Chikako Hirashima; Akihide Ohkuchi; Shigeki Matsubara; Hirotada Suzuki; Kayo Takahashi; Rie Usui; Mitsuaki Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  31     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1541-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
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MeSH Terms
Antigens, CD / blood*
Blood Pressure
Chemistry, Clinical / standards*
Infant, Low Birth Weight
Infant, Newborn
Infant, Small for Gestational Age
Pre-Eclampsia / blood*
Pregnancy Trimester, Second / blood*
Pregnancy Trimester, Third / blood*
Receptors, Cell Surface / blood*
Reference Values
Reg. No./Substance:
0/Antigens, CD; 0/ENG protein, human; 0/Receptors, Cell Surface

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