Document Detail


Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure.
MedLine Citation:
PMID:  17431736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite recent intensive investigations, physiological and pathological role of semicarbazide-sensitive amine oxidase (SSAO) is far from clear. In this study, serum SSAO activity was determined, radiochemically, in various groups of uremic patients: haemodialysed (HD), peritoneally dialysed (PD) and those receiving conservative treatment but still not dialysed (ND), as well as in controls. Reduced enzyme activity was found in HD uremic patients before and after dialysis treatment, compared to controls (5260 +/- 862 and 6011 +/- 958 pmol/h/ml vs. 8601 +/- 283 pmol/h/ml, p < 0.01 and p < 0.05, respectively). The activity was slightly lower in PD, and normal in ND patients. In HD patients SSAO activity was also determined by an assay based on the formation of hydrogen peroxide, and was found to be elevated compared to controls (2384 +/- 323 pmol/h/ml vs. 1437 +/- 72 pmol/h/ml, p < 0.05). The elevated serum SSAO activity measured through the detection of the enzyme-generated hydrogen peroxide in HD patients might indicate its contribution to the accelerated atherosclerotic disease observed in uremia.
Authors:
J Nemcsik; E Szökö; Zs Soltész; E Fodor; L Toth; J Egresits; T Tábi; K Magyar; I Kiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-13
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  114     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  841-3     Citation Subset:  IM    
Affiliation:
Angiology and Nephrology Division, Institute of Internal Medicine, St Imre Teaching Hospital, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing) / analysis,  blood*
Biological Markers / analysis,  blood
Dialysis
Humans
Kidney / enzymology*,  physiopathology
Kidney Failure, Chronic / blood*,  enzymology*,  physiopathology
Up-Regulation / physiology
Uremia / blood,  enzymology,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; EC 1.4.3.6/Amine Oxidase (Copper-Containing)

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