Document Detail


Alteration and role of heat shock proteins in acute pancreatitis.
MedLine Citation:
PMID:  20883423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many etiological factors are involved in the pathogenesis of acute pancreatitis. The pathogenesis of acute pancreatitis has been attributed to such causes as trypsin autodigestion, pancreatic microcirculation malfunction, the calcium overload in pancreatic acinar cells, oxygen free radical injury, cytokine injury, and has been treated in detail in numerous reviews. More recently, heat shock proteins (HSP), particularly heat shock protein 60 (HSP60), have receive increasing attention as another possible factor in the pathogenesis and development of acute pancreatitis. This brief review aims to: (i) outline our current understanding of HSP and their role in pancreatitis; (ii) discuss the available evidences that suggest HSP's interplay between pancreas tissues and etiological agents; (iii) delineate the functional mechanisms of HSP proposed by different research groups, and offer new thinking in preventing and treating acute pancreatitis in general.
Authors:
Jia Yan Feng; Yong Yu Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  11     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Copyright Information:
© 2010 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Pathophysiology, Tongji University School of Medicine, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Apoptosis
Chaperonin 60 / physiology
HSP27 Heat-Shock Proteins / physiology
HSP70 Heat-Shock Proteins / physiology
Heat-Shock Proteins / chemistry,  physiology*
Humans
Inflammation Mediators / physiology
NF-kappa B / physiology
Pancreatitis / etiology*
Chemical
Reg. No./Substance:
0/Chaperonin 60; 0/HSP27 Heat-Shock Proteins; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Inflammation Mediators; 0/NF-kappa B

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